墨西哥东北部10种药用植物的抗克氏锥虫活性

Anti-Trypanosoma cruzi activity of 10 medicinal plants used in northeast Mexico.

作者信息

Molina-Garza Zinnia Judith, Bazaldúa-Rodríguez Aldo Fabio, Quintanilla-Licea Ramiro, Galaviz-Silva Lucio

机构信息

Universidad Autónoma de Nuevo León, UANL, Facultad de Ciencias Biológicas, Laboratorio de Patología Molecular, Ave. Universidad S/N, Cd. Universitaria, 66451 San Nicolás de los Garza, NL, Mexico.

Universidad Autónoma de Nuevo León, UANL, Facultad de Ciencias Biológicas, Laboratorio de Fitoquímica, Ave. Universidad S/N, Cd. Universitaria, 66451 San Nicolás de los Garza, NL, Mexico.

出版信息

Acta Trop. 2014 Aug;136:14-8. doi: 10.1016/j.actatropica.2014.04.006. Epub 2014 Apr 15.

DOI:10.1016/j.actatropica.2014.04.006

PMID:24742906

Abstract

The aim of this study was to screen the trypanocidal activity of plants used in traditional Mexican medicine for the treatment of various diseases related to parasitic infections. Cultured Trypanosoma cruzi epimastigotes were incubated for 96h with different concentrations of methanolic extracts obtained from Artemisia mexicana, Castela texana, Cymbopogon citratus, Eryngium heterophyllum, Haematoxylum brasiletto, Lippia graveolens, Marrubium vulgare, Persea americana, Ruta chalepensis and Schinus molle. The inhibitory concentration (IC50) was determined for each extract via a colorimetric method. Among the evaluated species, the methanolic extracts of E. heterophyllum, H. brasiletto, M. vulgare and S. molle exhibited the highest trypanocidal activity, showing percentages of growth inhibition between 88 and 100% at a concentration of 150μg/ml. These medicinal plants may represent a valuable source of new bioactive compounds for the therapeutic treatment of trypanosomiasis.

摘要

本研究的目的是筛选墨西哥传统医学中用于治疗各种寄生虫感染相关疾病的植物的杀锥虫活性。将培养的克氏锥虫前鞭毛体与从墨西哥蒿、德克萨斯卡斯泰拉、柠檬香茅、异叶刺芹、巴西苏木、灰莉、药用夏至草、鳄梨、芸香和秘鲁香脂中获得的不同浓度甲醇提取物孵育96小时。通过比色法测定每种提取物的抑制浓度（IC50）。在所评估的物种中，异叶刺芹、巴西苏木、药用夏至草和秘鲁香脂的甲醇提取物表现出最高的杀锥虫活性，在浓度为150μg/ml时生长抑制率在88%至100%之间。这些药用植物可能是治疗锥虫病的新生物活性化合物的宝贵来源。