Cipolla B, Guille F, Quemener V, Lévêque J M, Moulinoux J P, Lobel B
Service d'Urologie, Universitaire de Rennes.
Prog Urol. 1992 Feb;2(1):50-7.
Spermidine and spermine are ubiquitous polyamines which are intensely metabolised in the prostate. Polyamines are involved in the processes of proliferation and differentiation of normal and neoplastic cells. As the erythrocyte levels of these polyamines are correlated with the intratumoral levels, we assayed EPA in 45 controls, 66 patients with benign prostatic hypertrophy and 100 patients with prostatic cancer. Erythrocytic polyamines are markers of proliferation and prostatic metastases and can be used to distinguish between hormone-sensitive and hormone-resistant patients. Although non-specific, polyamines constitute circulating markers of the state of tumour proliferation of a given patient and definitely have a prognostic value which needs to be evaluated by further studies.
亚精胺和精胺是普遍存在的多胺，在前列腺中被强烈代谢。多胺参与正常细胞和肿瘤细胞的增殖与分化过程。由于这些多胺的红细胞水平与肿瘤内水平相关，我们检测了45名对照者、66名良性前列腺增生患者和100名前列腺癌患者的红细胞多胺（EPA）。红细胞多胺是增殖和前列腺转移的标志物，可用于区分激素敏感型和激素抵抗型患者。尽管多胺是非特异性的，但它们构成了特定患者肿瘤增殖状态的循环标志物，并且肯定具有预后价值，需要进一步研究来评估。
