Cipolla B, Moulinoux J P, Quemener V, Havouis R, Martin L A, Guille F, Lobel B
Service d'Urologie, Centre Hospitalier Regional et Universitaire de Rennes, France.
J Urol. 1990 Nov;144(5):1164-6. doi: 10.1016/s0022-5347(17)39682-9.
Abnormally high red blood cell polyamine levels were found in benign prostatic hyperplasia and in prostatic adenocarcinoma patients. In prostatic adenocarcinoma patients a relationship was noted between the importance of red blood cell spermidine and spermine concentrations, and the clinical stage of the disease (Whitmore classification). Considering prostatic adenocarcinoma patient populations, patients with metastases (groups 3 and 4) statistically differed from those without metastases (group 2). Furthermore, red blood cell polyamine level determination discriminated patients in the hormonal escape group (group 4) from those usually considered as hormone responsive (groups 2 and 3). No statistically significant correlation was observed between red blood cell polyamine levels and usual tumor markers (prostatic acid phosphatase and prostate specific antigen). These results confirmed that red blood cell polyamine levels must be considered as a circulating index of cell proliferation that might be of clinical importance during the long-term followup and treatment of prostatic adenocarcinoma patients.
在良性前列腺增生症患者和前列腺腺癌患者中发现红细胞多胺水平异常升高。在前列腺腺癌患者中，注意到红细胞亚精胺和精胺浓度与疾病临床分期（惠特莫尔分类法）之间存在关联。考虑前列腺腺癌患者群体，有转移的患者（3组和4组）与无转移的患者（2组）在统计学上存在差异。此外，红细胞多胺水平测定可区分激素逃逸组（4组）患者与通常被认为对激素有反应的患者（2组和3组）。未观察到红细胞多胺水平与常用肿瘤标志物（前列腺酸性磷酸酶和前列腺特异性抗原）之间存在统计学上的显著相关性。这些结果证实，红细胞多胺水平必须被视为细胞增殖的循环指标，这在前列腺腺癌患者的长期随访和治疗中可能具有临床重要性。
