Costa M, Furness J B, Pompolo S, Brookes S J, Bornstein J C, Bredt D S, Snyder S H
Department of Physiology, Flinders University of South Australia, Adelaide.
Neurosci Lett. 1992 Dec 14;148(1-2):121-5. doi: 10.1016/0304-3940(92)90819-s.
The distribution of nitric oxide synthase (NOS) immunoreactivity was investigated in the guinea-pig small intestine. There were many immunoreactive nerve cell bodies in the myenteric plexus but very few in submucous ganglia. NOS immunoreactivity was not found in non-neuronal cells except for rare mucosal endocrine cells. Abundant immunoreactive nerve fibres in both myenteric and submucous ganglia, and in the circular muscle, arose from myenteric nerve cells whose axons projected anally along the intestine. NOS immunoreactivity coexisted with VIP-immunoreactivity, but not with substance P immunoreactivity. We conclude that nitric oxide synthase is located in a sub-population of enteric neurons, amongst which are inhibitory motor neurons that supply the circular muscle layer.
研究了豚鼠小肠中一氧化氮合酶（NOS）免疫反应性的分布。肌间神经丛中有许多免疫反应性神经细胞体，但黏膜下神经节中很少。除了罕见的黏膜内分泌细胞外，非神经元细胞中未发现NOS免疫反应性。肌间和黏膜下神经节以及环行肌中有丰富的免疫反应性神经纤维，它们起源于肌间神经细胞，其轴突沿肠道向肛门方向投射。NOS免疫反应性与血管活性肠肽（VIP）免疫反应性共存，但与P物质免疫反应性不共存。我们得出结论，一氧化氮合酶位于肠神经元的一个亚群中，其中包括为环行肌层提供神经支配的抑制性运动神经元。
