Lim Myung Kwan, Suh Chang Hae, Kim Hyung Jin, Kim Sung Tae, Lee Jeong Seop, Kang Min Hee, Kim Ji Hye, Lee Jung Hee
Department of Radiology, Inha University Hospital College of Medicine, Choong-gu, Incheon, Korea.
Korean J Radiol. 2003 Apr-Jun;4(2):79-84. doi: 10.3348/kjr.2003.4.2.79.
To investigate the MR imaging and (1)H-MR spectroscopic findings of acute fire-related post-traumatic stress disorder (PTSD).
Sixteen patients (M:F=10:6; mean age, 16 years) with fire-related PTSD underwent MR imaging and (1)H-MR spectroscopy, and for control purposes, the procedures were repeated in eight age-matched normal volunteers. In all patients and controls, the regions of interest where data were acquired at MRS were the basal ganglia (BG), frontal periventricular white matter (FWM), and parietal periventricular white matter (PWM).
In all patients with PTSD, MR images appeared normal. In contrast, MRS showed that in the BG, NAA/Cr ratios were significantly lower in patients than in volunteers. This decrease did not, however, show close correlation with the severity of the neuropsychiatric symptoms. In patients, neither NAA/Cr ratios in FWM nor PWM, nor Cho/Cr ratios in all three regions, were significantly different from those in the control group.
Decreased NAA/Cr ratios in the BG, as seen at (1)H-MRS, might be an early sign of acute fire-related PTSD.
探讨急性火灾相关创伤后应激障碍（PTSD）的磁共振成像（MR）及氢质子磁共振波谱（1H-MRS）表现。
16例火灾相关PTSD患者（男∶女 = 10∶6；平均年龄16岁）接受了MR成像及1H-MRS检查，为作对照，对8名年龄匹配的正常志愿者重复上述检查。所有患者及对照者中，MRS采集数据的感兴趣区为基底节（BG）、额叶脑室周围白质（FWM）和顶叶脑室周围白质（PWM）。
所有PTSD患者的MR图像均正常。相比之下，MRS显示，患者BG中的N-乙酰天门冬氨酸/肌酸（NAA/Cr）比值显著低于志愿者。然而，这种降低与神经精神症状的严重程度并无密切相关性。患者FWM及PWM中的NAA/Cr比值，以及所有三个区域中的胆碱/肌酸（Cho/Cr）比值，与对照组相比均无显著差异。
1H-MRS显示BG中NAA/Cr比值降低可能是急性火灾相关PTSD的早期征象。
