Talbot Peter S
Division of Functional Brain Mapping, New York State Psychiatric Institute, 1051 Riverside Drive, Unit 31, New York, NY 10032, USA.
Curr Psychiatry Rep. 2004 Aug;6(4):274-9. doi: 10.1007/s11920-004-0077-x.
This paper reviews the molecular neuroimaging of anxiety disorders, and attempts to put recent advances in the context of previous findings. Knowledge of the metabolic correlates of symptom severity and treatment response in obsessive-compulsive disorder has been significantly extended, particularly response to selective serotonin reuptake inhibitor medication. However, the first neuroreceptor studies of serotonin transporter availability in obsessive-compulsive disorder have proved inconclusive, and further studies are anticipated. Reduced 5-HT1A receptor binding has been reported in panic disorder. Recent findings have extended the knowledge of hippocampal abnormalities in post-traumatic stress disorder, and have highlighted the complexity of the association between cortisol and the hippocampus in this disorder.
本文回顾了焦虑症的分子神经影像学，并试图将近期进展置于先前研究结果的背景下。关于强迫症症状严重程度和治疗反应的代谢相关性的知识已得到显著扩展，尤其是对选择性5-羟色胺再摄取抑制剂药物的反应。然而，强迫症中5-羟色胺转运体可用性的首批神经受体研究结果尚无定论，预计还会有进一步研究。惊恐障碍中已报告5-HT1A受体结合减少。近期研究结果扩展了创伤后应激障碍中海马体异常的知识，并突出了该障碍中皮质醇与海马体之间关联的复杂性。
