Zilov V G, Patyshakuliev A P, Rogacheva S K, Ivanova L I
Biull Eksp Biol Med. 1992 Nov;114(11):455-7.
An ability of substance P (15 nmol intracerebroventricularly) to transform functional properties of the hypothalamic feeding center manifested in escape reaction in response to threshold electrical stimulation of this motivation center in rabbits. Beta-adrenergic antagonists inderal and obsidan (0.25, 0.5 mg, respectively) injected intravenously were found to restore feeding elicited by electrostimulation of the hypothalamic feeding center. However, escape reaction, elicited from the feeding center under substance P was found unchanged after intravenous administration of 0.25 mg kalipsol. The data obtained suggested an important role of beta-adrenergic mechanisms in substance P transformation of the functional properties of the hypothalamic feeding centre.
P物质（脑室内注射15纳摩尔）能够改变下丘脑摄食中枢的功能特性，这一特性体现在对家兔该动机中枢的阈下电刺激所产生的逃避反应中。静脉注射β-肾上腺素能拮抗剂心得安和氧烯洛尔（分别为0.25毫克和0.5毫克）可恢复下丘脑摄食中枢电刺激所引发的进食行为。然而，静脉注射0.25毫克卡利普索后，发现P物质作用下由摄食中枢引发的逃避反应未发生改变。所获数据表明，β-肾上腺素能机制在P物质对下丘脑摄食中枢功能特性的转变中起重要作用。
