Matsumoto Kenji, Suzuki Wataru, Tanaka Keiji
Cognitive Brain Mapping Laboratory, RIKEN Brain Science Institute, 2-1 Hirosawa, Wako, Saitama 351-0198, Japan.
Science. 2003 Jul 11;301(5630):229-32. doi: 10.1126/science.1084204.
Choosing an action that leads to a desired goal requires an understanding of the linkages between actions and their outcomes. We investigated neural mechanisms of such goal-based action selection. We trained monkeys on a task in which the relation between visual cues, action types, and reward conditions changed regularly, such that the monkeys selected their actions based on anticipated reward conditions. A significant number of neurons in the medial prefrontal cortex were activated, after cue presentation and before motor execution, only by particular action-reward combinations. This prefrontal activity is likely to underlie goal-based action selection.
选择能导向预期目标的行动需要理解行动与其结果之间的联系。我们研究了这种基于目标的行动选择的神经机制。我们训练猴子完成一项任务，在该任务中视觉线索、行动类型和奖励条件之间的关系会定期变化，这样猴子就会根据预期的奖励条件来选择它们的行动。在内侧前额叶皮层中，有相当数量的神经元仅在特定的行动 - 奖励组合出现后、运动执行前被激活。这种前额叶活动可能是基于目标的行动选择的基础。
