Bijlsma J W, Van den Brink H R
Department of Rheumatology, University Hospital, Utrecht, The Netherlands.
Am J Reprod Immunol. 1992 Oct-Dec;28(3-4):231-4. doi: 10.1111/j.1600-0897.1992.tb00800.x.
Epidemiological and immunological evidence has suggested that female sex hormones may play a role in the etiology and course of autoimmune diseases such as rheumatoid arthritis (RA). In this review the present clinical data with regard to estrogens and RA are discussed, with emphasis on the possible preventive effect of oral contraceptives on the incidence of RA and on the possibility of using estrogens as adjuvant therapy in RA. It is concluded that oral contraceptives may mitigate or postpone the onset of RA slightly, but that estrogens are not able to alleviate the symptoms of RA. Presently there is no evidence to promote the use of estrogens in preventing or treating RA in females.
流行病学和免疫学证据表明，女性性激素可能在类风湿关节炎（RA）等自身免疫性疾病的病因和病程中发挥作用。在这篇综述中，讨论了目前关于雌激素与类风湿关节炎的临床数据，重点是口服避孕药对类风湿关节炎发病率的可能预防作用，以及使用雌激素作为类风湿关节炎辅助治疗的可能性。得出的结论是，口服避孕药可能会略微减轻或推迟类风湿关节炎的发病，但雌激素无法缓解类风湿关节炎的症状。目前没有证据支持在预防或治疗女性类风湿关节炎中使用雌激素。
