Chowdhury B, Adak M, Bose S K
Department of Biology, Memorial University of Newfoundland, St John's, Newfoundland A1B 3X9, Canada.
Lett Appl Microbiol. 2003;37(2):158-61. doi: 10.1046/j.1472-765x.2003.01370.x.
The objective of this study was to determine the antifungal activity of flurbiprofen against dermatophytes like Trichophyton, Microsporum and Epidermophyton species.
Susceptibility tests were performed against dermatophytes like Trichophyton, Microsporum and Epidermophyton species by the microbroth dilution method. Among the dermatophytes tested, Trichophyton, Microsporum and Epidermophyton species are remarkably susceptible to this compound (MIC(50): 8-16 microg ml(-1)). A yeast pathogen, Candida albicans, and a bacterium, Staphylococcus aureus, are also susceptible to flurbiprofen.
Flurbiprofen is a non-steroidal anti-inflammatory compound with strong antifungal activity, which is not found in two well known and medically used antifungal organic acids like benzoic and salicylic acids.
The present action of flurbiprofen on microbes indicates its future prospects as an antimicrobial agent against dermatophytes and yeast pathogens. However, in view of the anti-inflammatory property of flurbiprofen, its antifungal action may provide an additional advantage for use as a skin ointment.
本研究的目的是确定氟比洛芬对毛癣菌属、小孢子菌属和表皮癣菌属等皮肤癣菌的抗真菌活性。
采用微量肉汤稀释法对毛癣菌属、小孢子菌属和表皮癣菌属等皮肤癣菌进行药敏试验。在所测试的皮肤癣菌中，毛癣菌属、小孢子菌属和表皮癣菌属对该化合物高度敏感（MIC(50)：8 - 16微克/毫升）。一种酵母病原体白色念珠菌和一种细菌金黄色葡萄球菌也对氟比洛芬敏感。
氟比洛芬是一种具有强大抗真菌活性的非甾体抗炎化合物，这在两种著名的药用抗真菌有机酸苯甲酸和水杨酸中未发现。
氟比洛芬目前对微生物的作用表明其作为抗皮肤癣菌和酵母病原体的抗菌剂的未来前景。然而，鉴于氟比洛芬的抗炎特性，其抗真菌作用可能为用作皮肤软膏提供额外优势。
