乳糜泻与癌症的关联。
Association Between Celiac Disease and Cancer.
机构信息
Department of Systems Medicine, University of Rome "Tor Vergata", 00133 Rome, Italy.
Gastroenterology Unit, Policlinico Tor Vergata, 00133 Rome, Italy.
出版信息
Int J Mol Sci. 2020 Jun 10;21(11):4155. doi: 10.3390/ijms21114155.
Abstract
Celiac disease (CD) is a chronic enteropathy that develops in genetically susceptible individuals after the ingestion of gluten. There has been a substantial increase in CD prevalence in the last 50 years, and it is now estimated that this disease affects approximately 1% of the population in the Western world. In the large majority of cases, CD is a benign disease, characterized by the complete resolution of symptoms and a normal life expectancy after the onset of a gluten-free diet (GFD). However, failure to adhere to a strict GFD bears the risk of adverse events and increases mortality. A considerable number of studies have considered the possible association between CD and neoplasms. In particular, an increased risk of malignancies, such as cancers of the gastrointestinal tract and intestinal lymphomas, has been reported. In this review, we summarize and discuss the current evidence on the possible association between CD and cancer.
摘要
乳糜泻（CD）是一种慢性肠病，在摄入麸质后，易患该病的遗传易感个体中发展。在过去的 50 年中，CD 的患病率有了实质性的增加，现在估计这种疾病在西方世界的人群中影响约 1%。在绝大多数情况下，CD 是一种良性疾病，其特征是在开始无麸质饮食（GFD）后，症状完全缓解，预期寿命正常。然而，未能坚持严格的 GFD 会带来不良事件的风险，并增加死亡率。相当多的研究已经考虑了 CD 与肿瘤之间可能的关联。特别是，已经报道了恶性肿瘤的风险增加，例如胃肠道癌症和肠淋巴瘤。在这篇综述中，我们总结和讨论了 CD 与癌症之间可能的关联的现有证据。
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