精神分裂症患者的糖尿病和糖耐量受损
Diabetes mellitus and impaired glucose tolerance in patients with schizophrenia.
作者信息
Subramaniam Mythily, Chong Siow-Ann, Pek Elaine
机构信息
Research Unit, Institute of Mental Health and Woodbridge Hospital, 10 Buangkok View, Singapore 539747.
出版信息
Can J Psychiatry. 2003 Jun;48(5):345-7. doi: 10.1177/070674370304800512.
OBJECTIVES
This study aimed to establish the prevalence of diabetes mellitus (DM) and impaired glucose tolerance in patients with schizophrenia and to elucidate some of the factors associated with hyperglycemia.
METHODS
We studied a sample of 194 patients with schizophrenia. We determined fasting blood glucose and insulin levels at the start of the testing period; patients were given an oral glucose tolerance test after an overnight fast.
RESULTS
The overall prevalence of diabetes and impaired glucose tolerance in these patients was 16.0% and 30.9%, respectively. These rates were higher than those reported in the general population. Patients with disordered glucose homeostasis were significantly older (P = 0.005, Kruskal-Wallis test). There was no significant effect of sex or ethnicity on diabetes.
CONCLUSIONS
Our findings suggest that patients with schizophrenia are more vulnerable to developing DM. We caution clinicians to be mindful of the increased risk and to be vigilant for such a development.
目的
本研究旨在确定精神分裂症患者中糖尿病（DM）和糖耐量受损的患病率，并阐明一些与高血糖相关的因素。
方法
我们研究了194例精神分裂症患者的样本。在测试期开始时测定空腹血糖和胰岛素水平；患者在禁食过夜后进行口服葡萄糖耐量试验。
结果
这些患者中糖尿病和糖耐量受损的总体患病率分别为16.0%和30.9%。这些比率高于一般人群中报告的比率。葡萄糖稳态紊乱的患者年龄显著更大（P = 0.005，Kruskal-Wallis检验）。性别或种族对糖尿病无显著影响。
结论
我们的研究结果表明，精神分裂症患者更容易患糖尿病。我们提醒临床医生注意这种增加的风险，并对这种情况保持警惕。
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