Polito Ennio, Tosi Gian Marco, Toti Paolo, Schürfeld Karin, Caporossi Aldo
Department of Ophthalmology and Neurosurgery, University of Siena, Via delle Scotte, 6, Italy.
Graefes Arch Clin Exp Ophthalmol. 2002 Jul;240(7):570-4. doi: 10.1007/s00417-002-0486-7. Epub 2002 Jun 20.
Solitary fibrous tumor (SFT) is a rare spindle cell tumor that arises most often in the visceral pleura; however, a review of the literature shows at least 31 cases occurring in the orbit.
A retrospective case series of three patients with orbital SFT: a 50-year-old man, observed in 1997, with an angioma-like lesion in the upper half of the orbit causing osteolysis of the orbital roof; a 24-year-old man, observed in 1992, with a superotemporal mass in the right orbit occupying the lacrimal gland region, firstly diagnosed as schwannoma, recurring 4 years after dacryoadenectomy; a 70-year-old man, with a retrobulbar mass diagnosed on a biopsy as hemangiopericytoma, recurring and infiltrating the orbital roof 4 years after surgery.
A review of the literature and presentation of three cases of SFT which showed infiltration of the orbital roof and/or recurrence.
Our cases provide evidence of how orbital SFT can behave aggressively and mimic other orbital tumors, thus making mandatory the consideration of this relatively new entity in common clinical practice as well as careful follow-up. Their aggressive growth is unusual, described in only 6 of the 31 cases so far reported in the literature. Immunohistochemistry is of importance for the diagnosis, since CD34 immunoreactivity is peculiar to SFT.
孤立性纤维性肿瘤（SFT）是一种罕见的梭形细胞肿瘤，最常发生于脏层胸膜；然而，文献回顾显示至少有31例发生于眼眶。
对3例眼眶SFT患者进行回顾性病例系列研究：1997年观察的一名50岁男性，眼眶上半部分有血管瘤样病变，导致眶顶骨质溶解；1992年观察的一名24岁男性，右眼眶颞上肿块占据泪腺区域，最初诊断为神经鞘瘤，泪腺切除术后4年复发；一名70岁男性，球后肿块活检诊断为血管外皮细胞瘤，术后4年复发并侵犯眶顶。
文献回顾及3例SFT病例报告显示有眶顶浸润和/或复发情况。
我们的病例证明眼眶SFT可表现为侵袭性并酷似其他眼眶肿瘤，因此在临床实践中必须考虑这一相对较新的实体，并进行仔细随访。其侵袭性生长并不常见，在迄今文献报道的31例中仅有6例描述过。免疫组织化学对诊断很重要，因为CD34免疫反应性是SFT所特有的。
