Walsh Bruce
Departments of Ecology and Evolutionary Biology, Molecular and Cellular Biology, and Plant Sciences, University of Arizona, Tucson, AZ 85721, USA.
Genetica. 2003 Jul;118(2-3):279-94.
The ultimate fate of a duplicated gene is that it either silenced through inactivating mutations or both copies are maintained by selection. This later fate can occur via neofunctionalization wherein one copy acquires a new function or by subfunctionalization wherein the original function of the gene is partitioned across both copies. The relative probabilities of these three different fates involve often very subtle iterations between of population size, mutation rate, and selection. All three of these fates are critical to the expansion and diversification of gene families.
复制基因的最终命运是，它要么通过失活突变而沉默，要么两个拷贝都通过选择得以保留。后一种命运可以通过新功能化发生，即其中一个拷贝获得新功能，或者通过亚功能化发生，即基因的原始功能在两个拷贝之间划分。这三种不同命运的相对概率通常涉及种群大小、突变率和选择之间非常微妙的相互作用。这三种命运对于基因家族的扩展和多样化都至关重要。
