Nafstad Per, Nystad Wenche, Magnus Per, Jaakkola Jouni J K
Division Epidemiology, Norwegian Institute of Public Health, Oslo, Norway.
J Asthma. 2003 Jun;40(4):343-8. doi: 10.1081/jas-120018633.
It has been suggested that consumption of fish and polyunsaturated fatty acids could have a protective effect against inflammation in the airways and the development of asthma and other allergic diseases. Our objective was to test the hypothesis that fish consumption during the first year of life decreases the risk of childhood asthma and allergic rhinitis. We assessed the relation between introduction of fish in the diet during the first year of life and risk of asthma and allergic rhinitis in a prospective 4-year cohort study of 2531 Norwegian children. We estimated odds ratios (OR) in logistic regression analysis adjusting for potential confounders. A total of 47.6% children had fish during the first year of life. The adjusted OR for allergic rhinitis was 0.45 (95% confidence interval [CI]=0.28, 0.74) and for asthma 0.84 (95% CI=0.57, 1.22). Fish consumption in the first year of life may reduce the risk of developing asthma and allergic rhinitis in childhood.
有人提出，食用鱼类和多不饱和脂肪酸可能对气道炎症以及哮喘和其他过敏性疾病的发展具有保护作用。我们的目标是检验这样一个假设：在生命的第一年食用鱼类可降低儿童患哮喘和过敏性鼻炎的风险。在一项对2531名挪威儿童进行的为期4年的前瞻性队列研究中，我们评估了生命第一年饮食中引入鱼类与哮喘和过敏性鼻炎风险之间的关系。我们在逻辑回归分析中估计比值比（OR），并对潜在混杂因素进行了调整。共有47.6%的儿童在生命的第一年食用了鱼类。过敏性鼻炎的调整后OR为0.45（95%置信区间[CI]=0.28, 0.74），哮喘的调整后OR为0.84（95%CI=0.57, 1.22）。生命第一年食用鱼类可能会降低儿童患哮喘和过敏性鼻炎的风险。
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