Shaker Reza, Castell Donald O, Schoenfeld Philip S, Spechler Stuart J
Medical College of Wisconsin Dysphagia Institute, Division of Gastroenterology and Hepatology, Milwaukee, Wisconsin, USA.
Am J Gastroenterol. 2003 Jul;98(7):1487-93. doi: 10.1111/j.1572-0241.2003.07531.x.
Although a large body of information exists about the prevalence of gastroesophageal reflux disease (GERD) in general, available data specifically addressing nocturnal reflux are limited. Because nocturnal acid reflux is reported to be associated with more severe injuries such as esophagitis and stricture, as well as adenocarcinoma of the esophagus, a better understanding of the prevalence and impact of nighttime heartburn as a sign of nocturnal acid reflux events can have significant potential management implications. The aims of this study were to determine the prevalence of nighttime heartburn and reflux-attributed supraesophageal symptoms among patients with GERD; and the impact of nighttime heartburn on sleep and several activities of daily living that could affect quality of life.
A nationwide telephone survey of 1000 adults experiencing heartburn at least once a week was conducted by the Gallup Organization on behalf of the American Gastroenterological Association.
Altogether, 79% of respondents reported experiencing heartburn at night. Among those, 75% reported that symptoms affected their sleep, 63% believed that heartburn negatively affected their ability to sleep well, and 40% believed that nocturnal heartburn impaired their ability to function the following day. Of the 791 respondents with nighttime heartburn, 71% reported taking over-the-counter medicine for it, but only 29% of these rated this approach extremely effective. Forty-one percent reported trying prescription medicines, and 49% of these rated this approach extremely effective.
Nighttime heartburn occurs in a large majority of adults with GERD, resulting in sleeping difficulties and impaired next-day function. The expected result from implemented therapy for heartburn is not achieved by a sizable percentage of patients.
尽管关于胃食管反流病（GERD）的总体患病率已有大量信息，但专门针对夜间反流的现有数据有限。由于据报道夜间酸反流与诸如食管炎、狭窄以及食管腺癌等更严重的损伤相关，因此更好地了解夜间烧心作为夜间酸反流事件标志的患病率及其影响，可能对治疗具有重要的潜在意义。本研究的目的是确定GERD患者中夜间烧心和反流所致食管外症状的患病率；以及夜间烧心对睡眠和可能影响生活质量的几项日常生活活动的影响。
盖洛普民意调查公司代表美国胃肠病学会对1000名每周至少经历一次烧心的成年人进行了全国性电话调查。
总共，79%的受访者报告有夜间烧心症状。其中，75%的人报告症状影响了他们的睡眠，63%的人认为烧心对他们良好睡眠的能力有负面影响，40%的人认为夜间烧心损害了他们第二天的功能。在791名有夜间烧心症状的受访者中，71%的人报告为此服用非处方药，但其中只有29%的人认为这种方法非常有效。41%的人报告尝试过处方药，其中49%的人认为这种方法非常有效。
大多数GERD成年患者会出现夜间烧心，导致睡眠困难和次日功能受损。相当一部分患者未达到烧心治疗的预期效果。
