Department of Internal Medicine, Fujitsu Clinic, Kawasaki City, 4-1-1 Kamikodanaka, Nakahara-Ku, Kanagawa Prefecture, 211-8588, Japan.
Health Promotion Unit, Fujitsu Limited, Kawasaki, Kanagawa, Japan.
Indian J Gastroenterol. 2023 Aug;42(4):542-548. doi: 10.1007/s12664-023-01366-4. Epub 2023 Jun 24.
Nonrestorative sleep (NRS) is a symptom of insomnia and is clearly more associated with objective indices than other insomnia symptoms. Gastroesophageal reflux disease (GERD) and insomnia are known to be strongly related. However, the link between NRS and heartburn, a main symptom of GERD, is poorly understood. Therefore, the relationships between them were investigated in addition to sleep duration.
The results of a single year's medical examinations were investigated for 29,475 Japanese active office workers who were 20 to 59 years old. NRS and heartburn were investigated in a medical interview using a personal computer. The relationships between NRS and heartburn in addition to sleep duration were also analyzed.
The subjects were 46.6 ± 8.7 years old (mean ± SD) and 27% and 13% of them had NRS and heartburn, respectively. The presence of NRS together with a sleep duration of ≤ 5, 6, 7 or ≥ 8 hours was an independent comorbid factor for heartburn compared with the absence of NRS together with a sleep duration of seven hours (reference; odds ratio [OR], 2.38; 95% confidence interval [CI], 2.11-2.69, OR, 2.44; 95% CI, 2.16-2.76, OR, 2.33; 95% CI, 1.94-2.79; and OR, 1.72; 95% CI, 1.14-2.52). The absence of NRS together with a sleep duration of ≤ 5 hours was also an independent comorbid factor for heartburn compared with the reference (OR, 1.20; 95% CI, 1.05-1.37).
NRS in active workers may contribute to heartburn comorbidity despite the sleep duration as in other workers without NRS.
非恢复性睡眠（NRS）是失眠的症状，与客观指标的相关性明显强于其他失眠症状。胃食管反流病（GERD）和失眠之间的关系众所周知。然而，NRS 与 GERD 的主要症状烧心之间的联系知之甚少。因此，除了睡眠时间外，还研究了它们之间的关系。
对 29475 名年龄在 20 至 59 岁的日本在职活跃员工进行了为期一年的体检结果调查。使用个人电脑在医学访谈中调查 NRS 和烧心。还分析了 NRS 与烧心以及睡眠时间之间的关系。
研究对象的年龄为 46.6±8.7 岁（平均值±标准差），分别有 27%和 13%的人存在 NRS 和烧心。与不存在 NRS 且睡眠时间为 7 小时相比，同时存在 NRS 且睡眠时间≤5、6、7 或≥8 小时是烧心的独立共病因素（比值比 [OR]，2.38；95%置信区间 [CI]，2.11-2.69，OR，2.44；95% CI，2.16-2.76，OR，2.33；95% CI，1.94-2.79；和 OR，1.72；95% CI，1.14-2.52）。同时不存在 NRS 且睡眠时间≤5 小时也是烧心的独立共病因素（OR，1.20；95% CI，1.05-1.37）。
在活跃的员工中，即使睡眠时间与没有 NRS 的其他员工相同，NRS 也可能导致烧心共病。
