Chen Chien-Lin, Robert Jennifer J T, Orr William C
Department of Medicine, Buddhist Tzu Chi General Hospital and University School of Medicine, Hualien, Taiwan.
J Clin Gastroenterol. 2008 Jan;42(1):13-7. doi: 10.1097/MCG.0b013e31802fc1bc.
This study was to determine whether patients with significant nighttime heartburn had more disturbed sleep and more gastroesophageal acid reflux than those without significant nighttime heartburn.
Thirty-three reflux patients were stratified into 2 groups (nighttime heartburn, without nighttime heartburn). All patients completed questionnaires assessing daytime and nighttime heartburn and subjective sleep by Pittsburgh Sleep Quality Index. All participants underwent 24-hour esophageal pH monitoring and an overnight polysomnographic study.
The number of reflux events longer than 5 minutes was significantly greater in patients with nighttime heartburn than in those without nighttime heartburn for the total (P=0.004) and upright (P=0.01) position periods. Acid contact time was significantly greater in patients with nighttime heartburn during the upright (P=0.003) period and during the total (P=0.001) period. Patients with nighttime heartburn reported significantly greater subjective sleep impairment (8.1+/-0.7) than those without nighttime heartburn (6.1+/-0.4; P=0.02), but no difference could be observed in any objective sleep parameter by an overnight polysomnographic study between the groups.
Patients with significant nighttime heartburn seem to have more acid reflux compared with those without nighttime heartburn. Nighttime heartburn together with sleep complaints is associated with excessive gastroesophageal reflux.
本研究旨在确定夜间严重烧心的患者与无夜间严重烧心的患者相比，是否有更紊乱的睡眠和更多的胃食管酸反流。
33例反流患者被分为两组（夜间烧心组、无夜间烧心组）。所有患者均完成问卷调查，通过匹兹堡睡眠质量指数评估白天和夜间烧心情况以及主观睡眠情况。所有参与者均接受24小时食管pH监测和整夜多导睡眠图研究。
夜间烧心患者反流事件持续超过5分钟的次数在总体（P = 0.004）和直立位（P = 0.01）期间显著多于无夜间烧心的患者。夜间烧心患者在直立位（P = 0.003）和总体（P = 0.001）期间的酸接触时间显著更长。夜间烧心患者报告的主观睡眠障碍（8.1±0.7）显著高于无夜间烧心的患者（6.1±0.4；P = 0.02），但两组间整夜多导睡眠图研究的任何客观睡眠参数均未观察到差异。
与无夜间烧心的患者相比，夜间严重烧心的患者似乎有更多的酸反流。夜间烧心伴睡眠主诉与胃食管反流过多有关。
