Krishna Mallela M G, Lin Yan, Rumbley Jon N, Englander S Walter
Department of Biochemistry and Biophysics, Johnson Research Foundation, University of Pennsylvania School of Medicine, 422 Curie Blvd, 1007 Stellar Chance Bldg, Philadelphia, PA 19104-6059, USA.
J Mol Biol. 2003 Aug 1;331(1):29-36. doi: 10.1016/s0022-2836(03)00697-1.
Hydrogen exchange experiments under slow exchange conditions show that an omega loop in cytochrome c (residues 40-57) acts as a cooperative unfolding/refolding unit under native conditions. This unit behavior accounts for an initial step on the unfolding pathway, a final step in refolding, and a number of other structural, functional and evolutionary properties.
在缓慢交换条件下进行的氢交换实验表明，细胞色素c中的一个Ω环（残基40 - 57）在天然条件下作为一个协同的去折叠/再折叠单元。这种单元行为解释了去折叠途径中的初始步骤、再折叠中的最终步骤以及许多其他结构、功能和进化特性。
