Kuehler A, Henrich G, Schroeder U, Conrad B, Herschbach P, Ceballos-Baumann A
Department of Neurology, Klinikum Rechts der Isar, Technische Universität München, Möhlstrasse 28, D-81675 Munich, Germany.
J Neurol Neurosurg Psychiatry. 2003 Aug;74(8):1023-30. doi: 10.1136/jnnp.74.8.1023.
To develop a short instrument to examine quality of life (QoL) which specifically addresses patients with movement disorders treated by deep brain stimulation (DBS).
The instrument was developed within an existing concept of a modular questionnaire (questions on life satisfaction: "general life satisfaction" QLS(M)-A, and "satisfaction with health" QLS(M)-G), in which each item is weighted according to its relative importance to the individual.
Items were generated by interviews with 20 DBS patients, followed by item reduction and scale generation, factor analysis to determine relevant and final questionnaire items, estimation of reliability, and validation based on the medical outcome study 36 item short form health survey (SF-36) and the EuroQol (EQ-5D) (data from 152 patients with Parkinson's disease, essential tremor, or idiopathic torsion dystonia, including 75 patients with DBS).
Initial questionnaires were reduced to 12 items for a "movement disorder module" (QLS(M)-MD), and five items for a "deep brain stimulation module" (QLS(M)-DBS). Psychometric analysis revealed Cronbach's alpha values of of 0.87 and 0.73, and satisfactory correlation coefficients for convergent validity with SF-36 and EQ-5D.
QLS(M)-MD and QLS(M)-DBS can evaluate quality of life aspects of DBS in movement disorders. Psychometric evaluation showed the questionnaires to be reliable, valid, and well accepted by the patients.
开发一种简短工具，用于检查生活质量（QoL），该工具专门针对接受深部脑刺激（DBS）治疗的运动障碍患者。
该工具是在模块化问卷的现有概念（关于生活满意度的问题：“总体生活满意度”QLS(M)-A和“健康满意度”QLS(M)-G）基础上开发的，其中每个项目根据其对个体的相对重要性进行加权。
通过对20名DBS患者进行访谈生成项目，随后进行项目精简和量表生成、因子分析以确定相关及最终问卷项目、可靠性估计，并基于医学结局研究36项简短健康调查（SF-36）和欧洲生活质量量表（EQ-5D）（来自152例帕金森病、特发性震颤或特发性扭转性肌张力障碍患者的数据，包括75例接受DBS治疗的患者）进行验证。
最初的问卷被精简为一个“运动障碍模块”（QLS(M)-MD）的12个项目和一个“深部脑刺激模块”（QLS(M)-DBS）的5个项目。心理测量分析显示Cronbach's alpha值分别为0.87和0.73，与SF-36和EQ-5D的收敛效度的相关系数令人满意。
QLS(M)-MD和QLS(M)-DBS可以评估运动障碍中DBS的生活质量方面。心理测量评估表明问卷可靠、有效且患者易于接受。
