Hickey W F
Department of Pathology, Dartmouth Medical School, DHMC, Lebanon, NH 03756, USA.
Semin Immunol. 1999 Apr;11(2):125-37. doi: 10.1006/smim.1999.0168.
While the central nervous system has long been considered immunologically privileged, over the past decade it has become evident that a wide variety of leukocyte types traffic through the nervous system. It is also apparent that the rules governing the trafficking of these disparate cell types are different for each. Some arrive, and probably depart, continuously as part of normal physiology. Others only appear to seek a specific antigen or in response to tissue damage. In this review the nature and function of individual cell types are discussed and our current knowledge regarding the parameters governing their entry into the CNS is examined.
虽然长期以来中枢神经系统一直被认为具有免疫特权，但在过去十年中，很明显有多种白细胞类型在神经系统中流动。同样明显的是，控制这些不同细胞类型流动的规则各不相同。一些细胞作为正常生理的一部分持续到达，可能也持续离开。另一些细胞似乎只是为了寻找特定抗原或对组织损伤做出反应才出现。在这篇综述中，我们讨论了个体细胞类型的性质和功能，并审视了我们目前关于控制它们进入中枢神经系统的参数的知识。
