Lee Sanghyun, Shin Dong-Sun, Kim Ju Sun, Oh Ki-Bong, Kang Sam Sik
Natural Products Research Institute, Seoul National University, Seoul 110-460, Korea.
Arch Pharm Res. 2003 Jun;26(6):449-52. doi: 10.1007/BF02976860.
Systematic fractionation of Angelica gigas roots led to the isolation of linear furano(pyrano)coumarins such as bergapten (1), decursinol angelate (2), decursin (3), nodakenetin (4) and nodakenin (5). The antibacterial activities of those compounds against pathogenic bacteria were investigated. Among the compounds tested, decursinol angelate (2) and decursin (3) exhibited significant antibacterial activity against Bacillus subtilis with the minimum inhibitory concentrations (MICs) of 50 and 12.5 microg/mL, respectively.
对当归根进行系统分离，得到了线性呋喃（吡喃）香豆素，如补骨脂素（1）、紫花前胡醇当归酸酯（2）、紫花前胡醇（3）、紫花前胡苷元（4）和紫花前胡苷（5）。研究了这些化合物对病原菌的抗菌活性。在所测试的化合物中，紫花前胡醇当归酸酯（2）和紫花前胡醇（3）对枯草芽孢杆菌表现出显著的抗菌活性，其最低抑菌浓度（MIC）分别为50和12.5μg/mL。
