Tan Nur, Yazıcı-Tütüniş Seçil, Bilgin Merve, Tan Emir, Miski Mahmut
Department of Pharmacognosy, Faculty of Pharmacy, Istanbul University, Istanbul 34116, Turkey.
Department of Pharmaceutical Microbiology, Faculty of Pharmacy, Istanbul Yeni Yuzyil University, Istanbul 34110, Turkey.
Molecules. 2017 Jul 1;22(7):1098. doi: 10.3390/molecules22071098.
The dichloromethane extract of the roots of , a recently described endemic species from Turkey, has yielded nine known and one new prenylated coumarins. The structures were elucidated by spectroscopic methods and direct comparison with the reference compounds where available. The root extract and its prenylated coumarins exhibit antimicrobial activity against nine standard and six clinically isolated strains at a concentration between 5 and 125 µg/mL. In particular, the new coumarin, 4'-senecioiloxyosthol (), displayed 5 µg/mL MIC (Minimum Inhibitory Concentration) value against ATCC 9372, murraol () and auraptenol () showed 63 µg/mL MIC value against ATCC 4352 and ATCC 9372, and isoimperatorin () exhibited 16 µg/mL MIC value.
一种最近被描述的来自土耳其的特有物种的根部二氯甲烷提取物，已产生了九种已知的和一种新的异戊烯基香豆素。通过光谱方法并在有参考化合物时与参考化合物直接比较来阐明结构。根部提取物及其异戊烯基香豆素在5至125μg/mL的浓度下对九种标准菌株和六种临床分离菌株表现出抗菌活性。特别是，新的香豆素4'-千里光酰氧基蛇床子素（）对嗜麦芽窄食单胞菌ATCC 9372显示出5μg/mL的最低抑菌浓度（MIC）值，穆拉醇（）和金雀异黄素（）对金黄色葡萄球菌ATCC 4352和嗜麦芽窄食单胞菌ATCC 9372显示出63μg/mL的MIC值，并异欧前胡素（）表现出16μg/mL的MIC值。
原文中部分括号内内容缺失具体化合物名称，翻译时保留括号。
