Malicka Joanna, Gryczynski Ignacy, Geddes Chris D, Lakowicz Joseph R
University of Maryland School of Medicine, Department of Biochemistry & Molecular Biology, Center for Fluorescence Spectroscopy, 725 W. Lombard Street, Baltimore, Maryland 21201-1503, USA.
J Biomed Opt. 2003 Jul;8(3):472-8. doi: 10.1117/1.1578643.
Indocyanine green (ICG) is widely used in medical imaging and testing. Its complex spectral behavior and low quantum yield limits some applications. We show that proximity of ICG to a metallic silver particle increases its intensity approximately 20-fold and decreases the decay time. Since the rate of photobleaching is not increased, our results suggest that ICG-silver particle complexes can yield at least 20-fold more photons per ICG molecule for improved medical imaging.
吲哚菁绿（ICG）广泛应用于医学成像和检测。其复杂的光谱行为和低量子产率限制了一些应用。我们发现，ICG靠近金属银颗粒会使其强度增加约20倍，并缩短衰减时间。由于光漂白速率没有增加，我们的结果表明，ICG-银颗粒复合物每个ICG分子可产生至少20倍以上的光子，从而改善医学成像。
