Nagata Chisato, Shimizu Hiroyuki, Takami Rieko, Hayashi Makoto, Takeda Noriyuki, Yasuda Keigo
Department of Public Health, Gifu University School of Medicine, 40 Tsukasa-machi, Gifu 500-8705, Japan.
Nutr Cancer. 2003;45(2):185-9. doi: 10.1207/S15327914NC4502_07.
Circulating levels of insulin-like growth factor-1 (IGF-1) and insulin-like growth factor-binding protein-3 (IGFBP-3) have each been associated with premenopausal breast cancer risks. We analyzed data from a cross-sectional study of 261 premenopausal Japanese women aged 20-54 yr with adequate nutritional status to evaluate the relationships between concentrations of IGF-1 and IGFBP-3 in serum and dietary intakes of soy, fats and other nutrients. Diet was assessed by a semiquantitative food frequency questionnaire. There was no significant correlation between soy product as well as soy isoflavone intake and serum IGF-1 or IGFBP-3 levels after controlling for age, total energy, percent body fat, and education level. Total fat intake was significantly inversely correlated with serum IGFBP-3 level (r = -0.13, P = 0.04). The correlations of saturated and monounsaturated fats with serum IGFBP-3 were of borderline significance (r = -0.12, P = 0.06 and r = -0.11, P = 0.07, respectively).
胰岛素样生长因子-1（IGF-1）和胰岛素样生长因子结合蛋白-3（IGFBP-3）的循环水平均与绝经前乳腺癌风险相关。我们分析了一项针对261名年龄在20 - 54岁、营养状况良好的绝经前日本女性的横断面研究数据，以评估血清中IGF-1和IGFBP-3浓度与大豆、脂肪及其他营养素的膳食摄入量之间的关系。饮食通过半定量食物频率问卷进行评估。在控制年龄、总能量、体脂百分比和教育水平后，大豆制品以及大豆异黄酮摄入量与血清IGF-1或IGFBP-3水平之间无显著相关性。总脂肪摄入量与血清IGFBP-3水平显著负相关（r = -0.13，P = 0.04）。饱和脂肪和单不饱和脂肪与血清IGFBP-3的相关性具有临界显著性（分别为r = -0.12，P = 0.06和r = -0.11，P = 0.07）。
