Channing Laboratory, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, 181 Longwood Avenue, Boston, MA 02115, USA.
Horm Cancer. 2010 Oct;1(5):265-76. doi: 10.1007/s12672-010-0050-6.
The authors conducted a cross-sectional study to investigate the associations of fat, fiber, and carbohydrate intake with endogenous estrogen, androgen, and insulin-like growth factor (IGF) levels among 595 premenopausal women. Overall, no significant associations were found between dietary intake of these macronutrients and plasma sex steroid hormone levels. Dietary fat intake was inversely associated with IGF-I and IGF-binding protein 3 (IGFBP-3) levels. When substituting 5% of energy from total fat for the equivalent amount of energy from carbohydrate or protein intake, the plasma levels of IGF-I and IGFBP-3 were 2.8% (95% confidence interval [CI] 0.3, 5.3) and 1.6% (95% CI 0.4, 2.8) lower, respectively. Animal fat, saturated fat, and monounsaturated fat intakes also were inversely associated with IGFBP-3 levels (P<0.05). Carbohydrates were positively associated with plasma IGF-I level. When substituting 5% of energy from carbohydrates for the equivalent amount of energy from fat or protein intake, the plasma IGF-I level was 2.0% (95% CI 0.1, 3.9%) higher. No independent associations between fiber intake and hormone levels were observed. The results suggest that a low-fat/high-fiber or carbohydrate diet is not associated with endogenous levels of sex steroid hormones, but it may modestly increase IGF-I and IGFBP-3 levels among premenopausal women.
作者进行了一项横断面研究,以调查 595 名绝经前妇女的脂肪、纤维和碳水化合物摄入与内源性雌激素、雄激素和胰岛素样生长因子 (IGF) 水平之间的关系。总的来说,这些宏量营养素的饮食摄入与血浆性激素水平之间没有显著关联。脂肪摄入与 IGF-I 和 IGF 结合蛋白 3 (IGFBP-3) 水平呈负相关。当用总脂肪中 5%的能量替代等量的碳水化合物或蛋白质摄入的能量时,IGF-I 和 IGFBP-3 的血浆水平分别降低了 2.8%(95%置信区间 [CI] 0.3,5.3)和 1.6%(95% CI 0.4,2.8)。动物脂肪、饱和脂肪和单不饱和脂肪的摄入也与 IGFBP-3 水平呈负相关(P<0.05)。碳水化合物与 IGF-I 呈正相关。当用碳水化合物中 5%的能量替代等量的脂肪或蛋白质摄入的能量时,IGF-I 的血浆水平升高了 2.0%(95% CI 0.1,3.9%)。纤维摄入与激素水平之间没有独立的关联。结果表明,低脂肪/高纤维或碳水化合物饮食与内源性性激素水平无关,但可能适度增加绝经前妇女的 IGF-I 和 IGFBP-3 水平。