Soldin Offie Porat, Pezzullo John C, Hanak Brian, Miller Maureen, Soldin Steven J
Soldin Research and Consultants, Inc., Bethesda, Maryland 20816, USA.
Ther Drug Monit. 2003 Aug;25(4):415-20. doi: 10.1097/00007691-200308000-00001.
To determine blood lead and zinc protoporphyrin (ZPP) concentrations in a pediatric population, confirm their interrelationship at low blood lead concentrations, and assess changing trends through comparison of these data with those found in a similar population 10 years earlier and to US national values.
The study was conducted in a large pediatric hospital in the Washington DC area (CNMC) on patient whole blood specimens (n = 4908) (0-17 years) accrued from January 2001 to June 2002. Pediatric blood lead concentrations were determined by atomic absorption spectrophotometry, and ZPP by hematofluorometry. The data were analyzed using a computer adaptation of the Hoffmann approach.
Blood lead level (BLL) means ranged between 2.2 and 3.3 micro g/dL, and the median BLL was 3 micro g/dL throughout. Mean ZPP concentrations ranged between 21.1 and 26.6 micro g/dL and the median concentrations between 21 and 27 micro g/dL. In comparison to data obtained from a similar pediatric population at CNMC between 1991 and 1992, pediatric BLLs have significantly declined in the Washington DC area. The current data are also compared with data obtained from the National Health and Nutrition Examination Survey (NHANES III) of the US population. The interrelationship between ZPP and BLLs is examined.
测定儿科人群的血铅和锌原卟啉（ZPP）浓度，确认低血铅浓度时它们之间的相互关系，并通过将这些数据与10年前在类似人群中发现的数据以及美国国家数据进行比较来评估变化趋势。
该研究在华盛顿特区地区的一家大型儿科医院（儿童国家医疗中心）进行，研究对象为2001年1月至2002年6月采集的患者全血标本（n = 4908）（0至17岁）。采用原子吸收分光光度法测定儿科血铅浓度，采用血液荧光测定法测定ZPP。使用霍夫曼方法的计算机适配程序对数据进行分析。
血铅水平（BLL）均值在2.2至3.3微克/分升之间，整个研究期间BLL中位数为3微克/分升。ZPP平均浓度在21.1至26.6微克/分升之间，中位数浓度在21至27微克/分升之间。与1991年至1992年期间在儿童国家医疗中心类似儿科人群中获得的数据相比，华盛顿特区地区儿科BLL显著下降。还将当前数据与从美国人群的国家健康和营养检查调查（NHANES III）中获得的数据进行比较。研究了ZPP与BLL之间的相互关系。
