Colegio Ciencias de Salud, Escuela de Medicina, Escuela de Salud Pública, Colegio de Artes Liberales y Galapagos Institute of Arts and Sciences GAIAS, Universidad San Francisco de Quito, Quito, Ecuador.
Clin Biochem. 2013 Sep;46(13-14):1233-8. doi: 10.1016/j.clinbiochem.2013.05.002. Epub 2013 May 14.
To investigate current lead (Pb) exposure in children living in Andean Ecuadorian communities. Blood Pb (PbB) and zinc protoporphyrin (ZPP) levels were used respectively as biomarkers of acute and chronic Pb poisoning. The current PbB-ZPP levels were compared with previous pediatric PbB-ZPP levels recorded over years in the study area.
Samples of whole blood were collected from 22 Andean children of Quechua and Mestizo backgrounds and measured for PbB concentrations by graphite furnace atomic absorption spectroscopy. ZPP/heme ratio and ZPP whole blood (ZPP WB) levels were measured with a hematofluorometer.
The mean PbB level for children in the current study group was 14.5 μg/dL, which was significantly lower than the mean PbB level of 41.1 μg/dL found in the same study area in the 1996-2000 test period, and lower than the 22.2 μg/dL mean level found in the 2003-2007 period. The current mean ZPP/heme ratio was 102.1 μmol/mol, and the mean ZPP WB level was 46.3 μg/dL, both lower than values previously found in children in the study area.
While the current pediatric PbB-ZPP levels in the study area remain elevated in some children, the overall levels indicate a decline relative to levels observed in the same Pb-contaminated area in the period between 1996 and 2007. The elevated ZPP levels suggest a history of chronic Pb exposure, and potential iron deficiency in some children. The overall reduction in PbB-ZPP levels suggests a positive outcome of a Pb-exposure education and prevention program, and the therapeutic intervention of succimer chelation therapy.
研究生活在安第斯厄瓜多尔社区的儿童当前的铅（Pb）暴露情况。血铅（PbB）和锌原卟啉（ZPP）水平分别作为急性和慢性 Pb 中毒的生物标志物。将当前的 PbB-ZPP 水平与该研究地区多年来记录的以前的儿科 PbB-ZPP 水平进行比较。
从 22 名具有克丘亚和梅斯蒂索背景的安第斯儿童采集全血样本，并通过石墨炉原子吸收光谱法测量 PbB 浓度。用血液荧光计测量 ZPP/血红素比和 ZPP 全血（ZPP WB）水平。
当前研究组儿童的平均 PbB 水平为 14.5μg/dL，明显低于 1996-2000 年检测期间同一研究地区的平均 PbB 水平 41.1μg/dL，也低于 2003-2007 年期间的平均 22.2μg/dL 水平。当前的平均 ZPP/血红素比为 102.1μmol/mol，平均 ZPP WB 水平为 46.3μg/dL，均低于该研究地区儿童以前的发现值。
虽然目前研究地区的儿科 PbB-ZPP 水平在一些儿童中仍然偏高，但总体水平与 1996 年至 2007 年期间同一 Pb 污染地区观察到的水平相比有所下降。ZPP 水平升高表明一些儿童存在慢性 Pb 暴露和潜在的铁缺乏史。PbB-ZPP 水平的整体降低表明 Pb 暴露教育和预防计划以及促排灵螯合疗法的治疗干预取得了积极成果。
