Bal Dit Sollier C, Caplain H, Drouet L
Experimental Thrombosis and Atherosclerosis Laboratory, IVS, Lariboisière Hospital, Paris, France.
Clin Lab Haematol. 2003 Aug;25(4):251-3. doi: 10.1046/j.1365-2257.2003.00527.x.
Some cases of spontaneous bleeding have been reported in patients treated with Ginkgo biloba. A prospective, double-blind, randomized, placebo-controlled study was carried out in 32 young male healthy volunteers to evaluate the effect of three doses of Ginkgo biloba extract (120, 240 and 480 mg/day for 14 days) on hemostasis, coagulation and fibrinolysis. This study did not reveal any alteration of platelet function or coagulation. This suggests that the reported clinical bleeding events in patients receiving Ginkgo biloba extract are not related to pharmacological properties of EGb761.
已有报道称，接受银杏叶治疗的患者出现了一些自发性出血的病例。对32名年轻男性健康志愿者进行了一项前瞻性、双盲、随机、安慰剂对照研究，以评估三种剂量的银杏叶提取物（120、240和480毫克/天，共14天）对止血、凝血和纤维蛋白溶解的影响。该研究未发现血小板功能或凝血有任何改变。这表明，接受银杏叶提取物治疗的患者所报告的临床出血事件与EGb761的药理特性无关。
