Hokanson John E, Langefeld Carl D, Mitchell Braxton D, Lange Leslie A, Goff David C, Haffner Steven M, Saad Mohammad F, Rotter Jerome I
Department of Preventive Medicine and Biometrics, University of Colorado Health Sciences Center, Denver, Colo. 80262, USA.
Hum Hered. 2003;55(1):46-50. doi: 10.1159/000071809.
Dyslipidemia is an important determinant of coronary disease. Phenotypic correlations between atherogenic lipids are well established, but the contribution of common genetic influences is less clear.
This study investigates the pair-wise genetic (rhog) and environmental (rhoe) correlations between apoB, LDL-C, HDL-C, and triglyceride (Tg) from Hispanic and African American families of the IRAS Family Study.
Heritability estimates (ĥ2) indicate significant genetic effects on apoB (ĥ2=0.46+/-0.05), LDL-C (ĥ2=0.40+/-0.05), HDL-C (ĥ2=0.47+/-0.05), and Tg (ĥ2=0.35+/-0.05) (all p<0.001). Genetic and environmental correlations were strong for apoB-LDL-C (rhog=0.87, rhoe=0.84), apoB-Tg (rhog=0.38, rhoe=0.65), and HDL-C-Tg (rhog=-0.42, rhoe=-0.46). Environmental correlations were strong for apoB-HDL-C (rhoe=-0.40), LDL-C-HDL-C (rhoe=-0.24), and Tg-LDL-C (rhoe=0.33) with weak genetic correlations for these pairs (rhog=-0.09, 0.10, 0.09 respectively).
These results suggest multiple pathways leading to atherogenic dyslipidemia. There are common genetic and environmental influences contributing to variations in apoB and LDL-C as well as apoB and Tg. In addition, the inverse relation between Tg and HDL-C appears to have both genetic and environmental basis. Identifying genes involved in atherogenic dyslipidemia will require careful dissection of the genetic architecture of these pathways.
血脂异常是冠心病的重要决定因素。致动脉粥样硬化脂质之间的表型相关性已得到充分证实，但常见遗传影响的作用尚不清楚。
本研究调查了IRAS家族研究中西班牙裔和非裔美国家庭的载脂蛋白B（apoB）、低密度脂蛋白胆固醇（LDL-C）、高密度脂蛋白胆固醇（HDL-C）和甘油三酯（Tg）之间的成对遗传（rhog）和环境（rhoe）相关性。
遗传力估计值（ĥ2）表明，apoB（ĥ2 = 0.46 ± 0.05）、LDL-C（ĥ2 = 0.40 ± 0.05）、HDL-C（ĥ2 = 0.47 ± 0.05）和Tg（ĥ2 = 0.35 ± 0.05）均存在显著的遗传效应（所有p < 0.001）。apoB与LDL-C（rhog = 0.87，rhoe = 0.84）、apoB与Tg（rhog = 0.38，rhoe = 0.65）以及HDL-C与Tg（rhog = -0.42，rhoe = -0.46）之间的遗传和环境相关性较强。apoB与HDL-C（rhoe = -0.40）、LDL-C与HDL-C（rhoe = -\(0.24\)）以及Tg与LDL-C（rhoe = 0.33）之间的环境相关性较强，而这些对之间的遗传相关性较弱（分别为rhog = -0.09、0.10、0.09）。
这些结果提示了导致动脉粥样硬化性血脂异常的多种途径。apoB和LDL-C以及apoB和Tg的变异存在共同的遗传和环境影响。此外，Tg与HDL-C之间的负相关似乎具有遗传和环境基础。识别参与动脉粥样硬化性血脂异常的基因需要仔细剖析这些途径的遗传结构。
