Hess Rebecka S, Kass Philip H, Van Winkle Thomas J
Department of Clinical Studies, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, PA 19104-6010, USA.
J Vet Intern Med. 2003 Jul-Aug;17(4):489-94. doi: 10.1111/j.1939-1676.2003.tb02469.x.
The objective of this study was to determine whether dogs with atherosclerosis are more likely to have concurrent diabetes mellitus, hypothyroidism, or hyperadrenocorticism than dogs that do not have atherosclerosis. A retrospective mortality prevalence case-control study was performed. The study group included 30 dogs with histopathological evidence of atherosclerosis. The control group included 142 dogs with results of a complete postmortem examination, a final postmortem examination diagnosis of neoplasia, and no histopathological evidence of atherosclerosis. Control dogs were frequency matched for age and year in which the postmortem examination was performed. Proportionate changes in the prevalence of diabetes mellitus, hypothyroidism, and hyperadrenocorticism were calculated by exact prevalence odds ratios (POR), 95% confidence intervals (95% CI), and P values. Multiple logistic regression analysis was used to examine the combined effects of prevalence determinants while controlling for age and year of postmortem examination. Dogs with atherosclerosis were over 53 times more likely to have concurrent diabetes mellitus than dogs without atherosclerosis (POR = 53.6; 95% CI, 4.6-627.5; P = .002) and over 51 times more likely to have concurrent hypothyroidism than dogs without atherosclerosis (POR = 51.1; 95% CI, 14.5-180.1; P < .001). Dogs with atherosclerosis were not found to be more likely to have concurrent hyperadrenocorticism than dogs that did not have atherosclerosis (POR = 1.8; 95% CI, 0.2-17.6; P = .59). Diabetes mellitus and hypothyroidism, but not hyperadrenocorticism, are more prevalent in dogs with atherosclerosis compared to dogs without atherosclerosis on postmortem examination.
本研究的目的是确定患有动脉粥样硬化的犬比未患动脉粥样硬化的犬更易并发糖尿病、甲状腺功能减退或肾上腺皮质功能亢进。进行了一项回顾性死亡率患病率病例对照研究。研究组包括30只具有动脉粥样硬化组织病理学证据的犬。对照组包括142只进行了完整尸检、尸检最终诊断为肿瘤且无动脉粥样硬化组织病理学证据的犬。对照犬在年龄和进行尸检的年份方面进行了频率匹配。通过精确患病率比值比（POR）、95%置信区间（95%CI）和P值计算糖尿病、甲状腺功能减退和肾上腺皮质功能亢进患病率的比例变化。采用多元逻辑回归分析来检验患病率决定因素的综合影响，同时控制年龄和尸检年份。患有动脉粥样硬化的犬并发糖尿病的可能性比未患动脉粥样硬化的犬高53倍以上（POR = 53.6；95%CI，4.6 - 627.5；P = 0.002），并发甲状腺功能减退的可能性比未患动脉粥样硬化的犬高51倍以上（POR = 51.1；95%CI，14.5 - 180.1；P < 0.001）。未发现患有动脉粥样硬化的犬比未患动脉粥样硬化的犬更易并发肾上腺皮质功能亢进（POR = 1.8；95%CI，0.2 - 17.6；P = 0.59）。与未患动脉粥样硬化的犬相比，在尸检中患有动脉粥样硬化的犬糖尿病和甲状腺功能减退更为普遍，但肾上腺皮质功能亢进并非如此。
