Mesich M L L, Mayhew P D, Paek M, Holt D E, Brown D C
Department of Clinical Studies, Matthew J. Ryan Veterinary Hospital, University of Pennsylvania, Philadelphia, PA 19104-6010, USA.
J Small Anim Pract. 2009 Dec;50(12):630-5. doi: 10.1111/j.1748-5827.2009.00811.x.
To investigate the relationship between endocrinopathies and diagnosis of gall bladder mucocele in dogs via a retrospective case-control study.
Records of 78 dogs with a surgical or ultrasonographic diagnosis of gall bladder mucocele were examined for the presence or absence of hyperadrenocorticism, hypothyroidism and diabetes mellitus. Two age- and breed-matched controls for each gall bladder mucocele dog (156 total control dogs) were examined for the same concurrent diseases. A matched case-control analysis was performed using conditional logistic regression.
The odds of mucocele in dogs with hyperadrenocorticism were 29 times that of dogs without hyperadrenocorticism (P=0.001; 95 per cent CI 3.8, 219.9). No difference was found between dogs with and without diabetes mellitus. Although a significant association was found between gall bladder mucocele and hypothyroidism, potential observation bias was also identifi ed.
Hyperadrenocorticoid dogs that were presented for acute illness with laboratory evidence of hepatobiliary disease should undergo evaluation for the presence of a biliary mucocele. Dogs diagnosed with a gall bladder mucocele should be screened for concurrent hyperadrenocorticism if clinical suspicion exists.
通过一项回顾性病例对照研究，调查犬内分泌疾病与胆囊黏液囊肿诊断之间的关系。
检查78只经手术或超声诊断为胆囊黏液囊肿的犬的记录，以确定是否存在肾上腺皮质功能亢进、甲状腺功能减退和糖尿病。为每只胆囊黏液囊肿犬匹配两只年龄和品种相符的对照犬（共156只对照犬），检查它们是否患有相同的并发疾病。使用条件逻辑回归进行匹配病例对照分析。
患有肾上腺皮质功能亢进的犬发生黏液囊肿的几率是未患肾上腺皮质功能亢进犬的29倍（P = 0.001；95%置信区间3.8，219.9）。患糖尿病和未患糖尿病的犬之间未发现差异。虽然发现胆囊黏液囊肿与甲状腺功能减退之间存在显著关联，但也发现了潜在的观察偏倚。
因急性疾病就诊且有肝胆疾病实验室证据的肾上腺皮质功能亢进犬，应评估是否存在胆管黏液囊肿。如果临床怀疑存在并发肾上腺皮质功能亢进，对诊断为胆囊黏液囊肿的犬应进行筛查。
