Kawa Keisei
Department of Pediatrics, Osaka Medical Center and Research Institute for Maternal and Child Health, Izumi City, Osaka, Japan.
Int J Hematol. 2003 Jul;78(1):24-31. doi: 10.1007/BF02983236.
Epstein-Barr virus (EBV) exhibits tropism for both lymphocytes and epithelial cells and can induce both replicative (productive/lytic) and latent (persistent) infections that result in a variety of human diseases. With regard to lymphocytes, latent EBV infection is linked to development of heterogeneous lymphoproliferative disease (LPD), such as B-cell LPD and T-cell/natural killer cell (T/NK cell) LPD. Unlike B-cell LPD, LPD derived from T-cells and NK cells sometimes has overlapping clinical symptoms, as well as histologic and immunophenotypic features, because both types of cells are derived from a common precursor. However, determination of cell lineage is important in classification of lymphoid neoplasms, and combined modern techniques allows us to distinguish NK cell LPD from T-cell LPD in most instances. Because NK cell LPD seems to be heterogeneous in terms of clinical features, prognosis, and diagnosis and has a monoclonal or polyclonal (or oligoclonal) nature, this review attempts to clarify recent research and clinical findings and to establish diagnostic and therapeutic strategies.
爱泼斯坦-巴尔病毒（EBV）对淋巴细胞和上皮细胞均具有嗜性，可引发复制性（增殖性/裂解性）感染和潜伏性（持续性）感染，从而导致多种人类疾病。就淋巴细胞而言，EBV潜伏感染与异质性淋巴增殖性疾病（LPD）的发生有关，如B细胞LPD和T细胞/自然杀伤细胞（T/NK细胞）LPD。与B细胞LPD不同，源自T细胞和NK细胞的LPD有时具有重叠的临床症状以及组织学和免疫表型特征，因为这两种细胞均来源于共同的前体细胞。然而，细胞谱系的确定在淋巴肿瘤的分类中很重要，现代技术的联合应用使我们能够在大多数情况下区分NK细胞LPD和T细胞LPD。由于NK细胞LPD在临床特征、预后和诊断方面似乎具有异质性，且具有单克隆或多克隆（或寡克隆）性质，本综述旨在阐明近期的研究和临床发现，并制定诊断和治疗策略。
