Sanghvi Y S, Vasseur J J, Debart F, Cook P D
Isis Pharmaceuticals, Carlsbad, CA 92008.
Nucleic Acids Symp Ser. 1992(27):133-4.
A convenient synthesis of a thymidine (T) nucleoside dimer (T-3'-CH2-O-NCH3-CH2-4'-T) 12 has been accomplished via a nucleoside coupling reaction. An alternative synthesis of 3'-deoxy-3'-C-hydroxymethyl-thymidine is described. The new dimer and methodology is useful for the development of backbone-modified antisense oligonucleosides.
通过核苷偶联反应已实现了胸苷（T）核苷二聚体（T-3'-CH2-O-NCH3-CH2-4'-T）12的简便合成。描述了3'-脱氧-3'-C-羟甲基胸苷的另一种合成方法。这种新的二聚体和方法学对于开发主链修饰的反义寡核苷酸很有用。
