Bryld Torsten, Wengel Jesper
Nucleic Acid Center, Department of Chemistry, University of Southern Denmark, Odense M, Denmark.
Nucleosides Nucleotides Nucleic Acids. 2003 May-Aug;22(5-8):1163-5. doi: 10.1081/NCN-120022826.
Synthesis of (1S,3R,4R,7R)-7-hydroxy-1-hydroxymethyl-3-(6-N-benzoyl-adenin-9-yl)-2,5-dioxabicyclo[2.2.1]heptane (2), a base-protected xylo-LNA adenine nucleoside, has been accomplished using a convergent synthetic strategy starting from 1,2-di-O-acetylfuranose 3.
已采用从1,2-二-O-乙酰呋喃糖3开始的汇聚合成策略完成了碱基保护的木糖-LNA腺嘌呤核苷(1S,3R,4R,7R)-7-羟基-1-羟甲基-3-(6-N-苯甲酰基-腺嘌呤-9-基)-2,5-二氧杂双环[2.2.1]庚烷(2)的合成。
