一种碱基保护的α-L-锁核酸鸟苷核苷的合成。
Synthesis of a base-protected alpha-L-LNA guanine nucleoside.
作者信息
Gaubert Gilles, Wengel Jesper
机构信息
Nucleic Acid Center, Department of Chemistry, University of Southern Denmark, Odense M, Denmark.
出版信息
Nucleosides Nucleotides Nucleic Acids. 2003 May-Aug;22(5-8):1155-7. doi: 10.1081/NCN-120022824.
PMID:14565368
Abstract
Synthesis of (1R,3R,4S,7R)-7-hydroxy-1-hydroxymethyl-3-(2-N-isobutyroylguanin-9-yl)-2,5-dioxabicyclo[2.2.1]heptane (12), a protected alpha-L-LNA guanine nucleoside, has been accomplished using a convergent synthetic strategy starting from 1,2-di-O-acetylfuranose 4.
摘要
(1R,3R,4S,7R)-7-羟基-1-羟甲基-3-(2-N-异丁酰基鸟嘌呤-9-基)-2,5-二氧杂双环[2.2.1]庚烷（12）是一种受保护的α-L-锁核酸鸟嘌呤核苷，其合成采用了从1,2-二-O-乙酰呋喃糖4开始的汇聚合成策略。
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