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波兰自制甲基卡西酮(去氧麻黄碱)引起的锰中毒。

Manganese Encephalopathy Caused by Homemade Methcathinone (Ephedrone) Prevalence in Poland.

机构信息

Department of Prevention and Treatment of Addictions, Institute of Psychiatry and Neurology, 02-957 Warsaw, Poland.

Department of Public Health, Medical University of Warsaw, 02-091 Warsaw, Poland.

出版信息

Nutrients. 2021 Oct 3;13(10):3496. doi: 10.3390/nu13103496.

DOI:10.3390/nu13103496
PMID:34684497
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8539983/
Abstract

Manganese encephalopathy is a known disorder in occupational medicine. A serious phenomenon has been the emergence of manganese encephalopathy in intravenous users of homemade methcathinone (ephedrone). A short survey was developed for clinical environments dealing with people who use psychoactive substances. The data were obtained from 72 rehabilitation therapy centers. Surveys carried out in about a third of Polish centers dealing with providing medical assistance to people addicted to substances other than alcohol and tobacco have shown that over 4% of people treated there had symptoms of manganese encephalopathy, of which more than half are people in whom the probability of a clinical diagnosis of this disorder is significant. It has been shown that knowledge of manganese encephalopathy is none or minimal in more than 70% of the surveyed institutions. An urgent need for personnel training in this field was pointed out. Attention was paid to the importance of disseminating good review articles on new and dynamically developing problem phenomena.

摘要

锰中毒性脑病是职业医学中已知的疾病。一个严重的现象是,在使用自制的苯丙胺(冰毒)的静脉注射者中出现了锰中毒性脑病。为处理使用精神活性物质者的临床环境开发了一个简短的调查。数据来自 72 个康复治疗中心。对波兰大约三分之一处理除酒精和烟草以外物质成瘾者提供医疗援助的中心进行的调查表明,那里接受治疗的超过 4%的人有锰中毒性脑病的症状,其中超过一半是这种疾病的临床诊断可能性较大的人。调查显示,超过 70%的被调查机构对锰中毒性脑病的了解为零或很少。有人指出迫切需要在这一领域开展人员培训。还注意到传播关于新的和动态发展的问题现象的良好综述文章的重要性。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d36a/8539983/b9199115c60c/nutrients-13-03496-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d36a/8539983/9a47de9b6b1b/nutrients-13-03496-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d36a/8539983/b9199115c60c/nutrients-13-03496-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d36a/8539983/9a47de9b6b1b/nutrients-13-03496-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d36a/8539983/b9199115c60c/nutrients-13-03496-g002.jpg

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Exposure to Manganese in Drinking Water during Childhood and Association with Attention-Deficit Hyperactivity Disorder: A Nationwide Cohort Study.儿童期饮用水中接触锰与注意缺陷多动障碍的关联:一项全国性队列研究。
Environ Health Perspect. 2020 Sep;128(9):97004. doi: 10.1289/EHP6391. Epub 2020 Sep 21.
2
Serum Levels of Selenium, Zinc, Copper, Manganese, and Iron in Prostate Cancer Patients.前列腺癌患者血清中硒、锌、铜、锰和铁的水平
Curr Urol. 2020 Mar;14(1):44-49. doi: 10.1159/000499261. Epub 2020 Mar 20.
3
Acute hyperkinetic syndrome due to ephedrone abuse.
因滥用甲基麻黄碱导致的急性运动增多综合征。
J Addict Med. 2015 May-Jun;9(3):244-5. doi: 10.1097/ADM.0000000000000048.
4
Modifying welding process parameters can reduce the neurotoxic potential of manganese-containing welding fumes.修改焊接工艺参数可以降低含锰焊接烟尘的神经毒性潜能。
Toxicology. 2015 Feb 3;328:168-78. doi: 10.1016/j.tox.2014.12.015. Epub 2014 Dec 27.
5
Methamphetamine/amphetamine abuse and risk of Parkinson's disease in Utah: a population-based assessment.犹他州甲基苯丙胺/苯丙胺滥用与帕金森病风险:一项基于人群的评估。
Drug Alcohol Depend. 2015 Jan 1;146:30-8. doi: 10.1016/j.drugalcdep.2014.10.027. Epub 2014 Nov 16.
6
Neurobehavioral function in school-age children exposed to manganese in drinking water.饮用水中接触锰的学龄儿童的神经行为功能。
Environ Health Perspect. 2014 Dec;122(12):1343-50. doi: 10.1289/ehp.1307918. Epub 2014 Sep 26.
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MRI brain findings in ephedrone encephalopathy associated with manganese abuse: Single-center perspective.与锰滥用相关的麻黄酮脑病的脑部磁共振成像表现:单中心视角
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