Till Christine, Rovet Joanne F, Koren Gideon, Westall Carol A
The Motherisk Program, The Research Institute, The Hospital for Sick Children, Toronto, Ontario, Canada.
Neurotoxicology. 2003 Aug;24(4-5):725-31. doi: 10.1016/S0161-813X(02)00212-7.
Prenatal exposure to organic solvents has been previously associated with increased risk of color vision deficits and reduced visual acuity in young children. These findings prompted us to evaluate visual functioning in solvent-exposed infants using more sensitive non-invasive visual evoked potential (VEP) techniques. VEP techniques are described in the context of an ongoing prospective longitudinal cohort study of infants exposed to organic solvents in utero. VEPs are recorded via three active electrodes fitted over the occipital cortex while infants view changing visual stimuli. The sweep VEP is used to assess contrast detection and visual acuity by presenting sinusoidal gratings that "sweep" across a range of contrasts and spatial frequencies. Transient VEPs are used to assess responses to equiluminant chromatic- and luminance-modulated sinusoidal gratings presented in pattern onset-offset format. A single case study is presented showing abnormal chromatic responses and reduced contrast sensitivity in a 2.5-year-old boy following prenatal exposure to perchloroethylene (PCE). These VEP techniques therefore appear promising for the clinical assessment of visual toxicity in pediatric populations.
先前已有研究表明，孕期接触有机溶剂会增加幼儿出现色觉缺陷和视力下降的风险。这些发现促使我们使用更灵敏的无创视觉诱发电位（VEP）技术，来评估接触过溶剂的婴儿的视觉功能。VEP技术是在一项正在进行的前瞻性纵向队列研究背景下进行描述的，该研究针对子宫内接触过有机溶剂的婴儿。当婴儿观看变化的视觉刺激时，通过放置在枕叶皮质上的三个有源电极记录VEP。扫描VEP通过呈现“扫描”一系列对比度和空间频率的正弦光栅，来评估对比度检测和视力。瞬态VEP用于评估对以模式起始-偏移格式呈现的等亮度色度和亮度调制正弦光栅的反应。本文呈现了一个单病例研究，该研究显示一名2.5岁男孩在产前接触过全氯乙烯（PCE）后出现了异常的色度反应和对比敏感度降低。因此，这些VEP技术在儿科人群视觉毒性的临床评估中似乎很有前景。
