Czuprynski Charles J, Faith Nancy G, Steinberg Howard, Neudeck Brien
Department of Pathobiological Sciences, School of Veterinary Medicine, University of Wisconsin-Madison, 2015 Linden Drive, Madison, WI 53706, USA.
Microb Pathog. 2003 Aug;35(2):81-6. doi: 10.1016/s0882-4010(03)00097-4.
In the present study we observed that mice anesthetized with sodium pentobarbital were far more susceptible to gastrointestinal challenge with Listeria monocytogenes than were unanaesthetized mice. The effect of pentobarbital anesthesia was transient (gone within 2 h) and did not alter the severity of infection following i.v. challenge with L. monocytogenes. Treatment with pharmacological inhibitors of gastric acidity (i.e. cimetidine and omeprazole), or intestinal motility (loperamide), did not duplicate the effect of pentobarbital on gastrointestinal listeriosis. These findings suggest that sodium pentobarbital anesthesia causes a short-lived but striking diminution in resistance to gastrointestinal listeriosis in mice, via an undefined mechanism.
在本研究中，我们观察到用戊巴比妥钠麻醉的小鼠比未麻醉的小鼠更容易受到单核细胞增生李斯特菌的胃肠道攻击。戊巴比妥麻醉的效果是短暂的（2小时内消失），并且在静脉注射单核细胞增生李斯特菌后不会改变感染的严重程度。用胃酸药理抑制剂（即西咪替丁和奥美拉唑）或肠道动力抑制剂（洛哌丁胺）进行治疗，并未重现戊巴比妥对胃肠道李斯特菌病的影响。这些发现表明，戊巴比妥钠麻醉通过一种不明机制，导致小鼠对胃肠道李斯特菌病的抵抗力出现短暂但显著的降低。
