Rennie K L, McCarthy N, Yazdgerdi S, Marmot M, Brunner E
Department of Epidemiology and Public Health, University College London, 1-19 Torrington Place, London WC1E 6BT, UK.
Int J Epidemiol. 2003 Aug;32(4):600-6. doi: 10.1093/ije/dyg179.
Cross-sectional relationships between moderate and vigorous physical activity and the metabolic syndrome (MS) were examined in the Whitehall II study of civil servants (age 45-68 years). We assessed cardiovascular fitness and body mass index (BMI) as possible mediators of the observed association.
Measures of 2-hour glucose, systolic blood pressure, fasting triglycerides, waist-hip ratio, and high density lipoprotein (HDL) cholesterol were obtained in 5153 white European participants. Participants in the most adverse sex-specific quintile for three or more of these risk factors were classified as having MS. Self-reported leisure-time physical activity was categorized into separate moderate and vigorous activity classes. BMI and resting heart rate (HR) were used to estimate body fatness and cardiovascular fitness respectively.
The odds ratios (95% CI) for having the metabolic syndrome in the top categories of vigorous and moderate activity were 0.52 (95% CI: 0.40, 0.67) and 0.78 (95% CI: 0.63, 0.96) respectively, adjusted for age, sex, smoking, alcohol intake, socioeconomic status, and other activity. Adjustment for BMI and resting HR substantially attenuated both of the above associations.
Moderate and vigorous physical leisure-time activity are each associated with reduced risk of being classified with MS independently of age, smoking, and high alcohol intake. Both vigorous and moderate activities may be beneficial to the MS cluster of risk factors among middle-aged populations. Reduced BMI and increased cardiovascular fitness may be important mediators of this association for both intensities of activity.
在白厅II公务员研究（年龄45 - 68岁）中，研究了中度和剧烈身体活动与代谢综合征（MS）之间的横断面关系。我们评估了心血管健康状况和体重指数（BMI）作为观察到的关联的可能中介因素。
对5153名欧洲白人参与者进行了2小时血糖、收缩压、空腹甘油三酯、腰臀比和高密度脂蛋白（HDL）胆固醇的测量。在这些风险因素中，有三个或更多处于最不利的特定性别五分位数的参与者被归类为患有MS。自我报告的休闲时间身体活动被分为单独的中度和剧烈活动类别。BMI和静息心率（HR）分别用于估计身体脂肪含量和心血管健康状况。
在剧烈活动和中度活动的最高类别中，患有代谢综合征的比值比（95%CI）分别为0.52（95%CI：0.40，0.67）和0.78（95%CI：0.63，0.96），对年龄、性别、吸烟、饮酒量、社会经济地位和其他活动进行了调整。对BMI和静息HR进行调整后，上述两种关联均大幅减弱。
中度和剧烈的休闲时间身体活动均与被归类为患有MS的风险降低相关，且独立于年龄、吸烟和高酒精摄入量。剧烈和中度活动可能对中年人群的MS风险因素集群均有益。BMI降低和心血管健康状况改善可能是这两种活动强度与MS关联的重要中介因素。
