Murray Liam, Johnston Brian, Lane Athene, Harvey Ian, Donovan Jenny, Nair Prakash, Harvey Richard
The Queen's University of Belfast, Belfast BT12 5BJ, UK.
Int J Epidemiol. 2003 Aug;32(4):645-50. doi: 10.1093/ije/dyg108.
To examine the relationship between body mass and gastro-oesophageal reflux in a large population-representative sample from the UK.
Cross-sectional population-based study, as part of a randomized controlled trial of eradication of Helicobacter pylori infection, in Southwest England. Subjects In all, 10 537 subjects, aged 20-59 years, were recruited from seven general practices. Subjects provided data on frequency and severity of dyspeptic symptoms and anthropometric measurements were taken.
Relationship between overweight (body mass index [BMI] >/=25 kg/m(2) and </=30 kg/m(2)) or obesity (BMI >30 kg/m(2)) and frequency and severity of heartburn and acid regurgitation.
Body mass index was strongly positively related to the frequency of symptoms of gastro-oesophageal reflux. The adjusted odds ratios (OR) for frequency of heartburn and acid regurgitation occurring at least once a week in overweight participants compared with those of normal weight were 1.82 (95% CI: 1.33-2.50) and 1.50 (95% CI: 1.13-1.99) respectively. Corresponding OR (95% CI) relating to obese patients were 2.91 (95% CI: 2.07-4.08) and 2.23 (95% CI: 1.44-3.45) respectively. The OR for moderate to severe reflux symptoms were raised in overweight and obese subjects but not to the same extent as frequency of symptoms and only the relationship between obesity and severity of heartburn reached conventional statistical significance: OR = 1.19; 95% CI: 1.07-1.33.
Being above normal weight substantially increases the likelihood of suffering from heartburn and acid regurgitation and obese people are almost three times as likely to experience these symptoms as those of normal weight.
在来自英国的具有人群代表性的大样本中，研究体重与胃食管反流之间的关系。
基于人群的横断面研究，作为根除幽门螺杆菌感染的随机对照试验的一部分，在英格兰西南部进行。研究对象 总共从7家全科诊所招募了10537名年龄在20至59岁之间的研究对象。研究对象提供了消化不良症状的频率和严重程度数据，并进行了人体测量。
超重（体重指数[BMI]≥25kg/m²且≤30kg/m²）或肥胖（BMI>30kg/m²）与烧心和反酸的频率及严重程度之间的关系。
体重指数与胃食管反流症状的频率呈强烈正相关。超重参与者与正常体重参与者相比，每周至少出现一次烧心和反酸症状的校正比值比（OR）分别为1.82（95%CI：1.33 - 2.50）和1.50（95%CI：1.13 - 1.99）。肥胖患者的相应OR（95%CI）分别为2.91（95%CI：2.07 - 4.08）和2.23（95%CI：1.44 - 3.45）。超重和肥胖受试者中，中至重度反流症状的OR有所升高，但程度不如症状频率，只有肥胖与烧心严重程度之间的关系达到传统统计学显著性：OR = 1.19；95%CI：1.07 - 1.33。
体重高于正常水平会大幅增加患烧心和反酸的可能性，肥胖者出现这些症状的可能性几乎是正常体重者的三倍。
