Jayalakshmi S, Venugopalan V K
CAS in Marine Biology, Annamalai University, Parangipettai.
Indian J Med Res. 1992 Nov;95:294-6.
V. vulnificus strains isolated from different sources of Cuddalore coastal waters were tested for their virulence activity through their LD50 values in mice. As infections of V. vulnificus have been correlated with pre-existing liver disease and hemochromatosis, the role of iron on virulence was determined using. iron overloaded mice. The LD50 was in the range of 10(4)-10(7) cells in normal mice but 10(1)-10(2) cells in iron-injected mice, thus providing evidence that iron may play a major role in the pathogenesis of V. vulnificus.
从库德洛尔沿海水域不同来源分离出的创伤弧菌菌株，通过其在小鼠体内的半数致死剂量（LD50）值来测试其毒力活性。由于创伤弧菌感染与既往存在的肝病和血色素沉着症相关，因此使用铁过载小鼠来确定铁对毒力的作用。正常小鼠的LD50在10⁴ - 10⁷个细胞范围内，而铁注射小鼠的LD50在10¹ - 10²个细胞范围内，从而证明铁可能在创伤弧菌的发病机制中起主要作用。
