Jauniaux E, Jurkovic D, Delogne-Desnoek J, Meuris S
Research Laboratory on Reproduction, Free University of Brussels (ULB), School of Medicine, Belgium.
Hum Reprod. 1992 Nov;7(10):1467-73. doi: 10.1093/oxfordjournals.humrep.a137596.
A transvaginal colour and pulsed Doppler study was performed on 44 women with normal pregnancies between 5 and 16 weeks of gestation. Maternal levels of human chorionic gonadotrophin (HCG), free alpha-HCG subunit, free beta-HCG subunit, 17 beta-oestradiol and progesterone were determined in sera obtained at the time of Doppler examination. Uterine peak systolic velocity (PSV) and alpha-HCG and 17 beta-oestradiol levels increased significantly (P < 0.001) from the second to the fourth month of gestation, whereas uterine and spiral resistance index (RI) decreased significantly (P < 0.005 and P < 0.001, respectively) with gestational age. Levels of HCG and beta-HCG peaked significantly (P < 0.01) during the third month of gestation. Corpus luteum PSV and RI and progesterone levels did not vary significantly with gestational age. Multiple regression analysis showed that gestational age was the only significant (P < 0.05) contributor to uterine PSV and spiral RI variability. In addition to gestational age, 17 beta-oestradiol had a significant (P < 0.001) influence on uterine RI. Both corpus luteum PSV and RI were significantly (P < 0.01 and P < 0.05, respectively) related to progesterone levels. Corpus luteum PSV was also significantly (P < 0.05) related to 17 beta-oestradiol levels and RI to HCG levels.(ABSTRACT TRUNCATED AT 250 WORDS)
对44名妊娠5至16周的正常孕妇进行了经阴道彩色和脉冲多普勒研究。在多普勒检查时采集的血清中测定母体人绒毛膜促性腺激素（HCG）、游离α-HCG亚基、游离β-HCG亚基、17β-雌二醇和孕酮水平。从妊娠第二个月到第四个月，子宫收缩期峰值速度（PSV）以及α-HCG和17β-雌二醇水平显著升高（P<0.001），而子宫和螺旋动脉阻力指数（RI）随孕周显著降低（分别为P<0.005和P<0.001）。HCG和β-HCG水平在妊娠第三个月时显著达到峰值（P<0.01）。黄体PSV、RI和孕酮水平随孕周无显著变化。多元回归分析表明，孕周是子宫PSV和螺旋动脉RI变异的唯一显著（P<0.05）影响因素。除孕周外？17β-雌二醇对子宫RI有显著（P<0.001）影响。黄体PSV和RI均与孕酮水平显著相关（分别为P<0.01和P<0.05）。黄体PSV也与17β-雌二醇水平显著相关（P<0.05），RI与HCG水平显著相关。（摘要截短至250字） （注：原文中“17 beta-oestradiol and progesterone were determined in sera obtained at the time of Doppler examination. Uterine peak systolic velocity (PSV) and alpha-HCG and 17 beta-oestradiol levels increased significantly (P < 0.001) from the second to the fourth month of gestation, whereas uterine and spiral resistance index (RI) decreased significantly (P < 0.005 and P < 0.001, respectively) with gestational age. Levels of HCG and beta-HCG peaked significantly (P < 0.01) during the third month of gestation. Corpus luteum PSV and RI and progesterone levels did not vary significantly with gestational age. Multiple regression analysis showed that gestational age was the only significant (P < 0.05) contributor to uterine PSV and spiral RI variability. In addition to gestational age, 17 beta-oestradiol had a significant (P < 0.001) influence on uterine RI. Both corpus luteum PSV and RI were significantly (P < 0.01 and P < 0.05, respectively) related to progesterone levels. Corpus luteum PSV was also significantly (P < 0.05) related to 17 beta-oestradiol levels and RI to HCG levels.”这段内容中“17 beta-oestradiol and progesterone were determined in sera obtained at the time of Doppler examination.”与前文逻辑联系不紧密，推测可能是多了个“？”，翻译时按正确逻辑进行了翻译，但整体内容逻辑上可能存在一定瑕疵，你可根据实际情况调整。）
