Brinkworth Grant D, Buckley Jonathan D
Centre for Research in Education and Sports Science Division of Health Sciences, University of South Australia, Holbrooks Road, Underdale, South Australia 5032, Australia.
Eur J Nutr. 2003 Aug;42(4):228-32. doi: 10.1007/s00394-003-0410-x.
Anecdotal reports suggest that bovine colostrum may prevent upper respiratory tract infection (URTI). There is scant evidence to support such claims, although salivary IgA protects against URTI, and it was recently shown that bovine colostrum increases salivary IgA.
The present invesigation examined whether concentrated bovine colostrum protein (CBC) affected the incidence or duration of self-reported symptoms of URTI in adult males.
We examined logbooks containing self-reported symptoms of illness from previous studies which examined physiological effects of CBC. In these double-blind, placebo controlled studies, subjects had been randomly allocated to consume 60g. day(-1) of CBC (n = 93) or whey protein (WP) (n = 81) for eight weeks. Symptoms were coded using established criteria to identify those related to URTI. Since the incubation period for an URTI is up to five days, symptoms reported during the first week of supplementation (PRE-EXP) were analysed separately to preclude those arising from infection prior to study commencement.
During PRE-EXP, there was no difference in the proportion of subjects taking the different supplements who reported symptoms of URTI (CBC, 11%,WP, 5%; 95% Confidence Interval (95% CI) -14% to 2%; P = 0.16). During the subsequent seven weeks (i. e. the experimental period), a significantly lesser proportion of subjects taking CBC reported symptoms of URTI compared with those taking WP (CBC, 32%,WP, 48%, P = 0.03; 95 % CI -30 % to -2 %), but symptom duration did not differ (CBC, 6.8 +/- 4.2 days,WP, 6.0 +/- 4.4 days; P = 0.27).
This study provides preliminary evidence that CBC may enhance resistance to the development of symptoms of URTI.
有传闻称牛初乳可能预防上呼吸道感染（URTI）。尽管唾液免疫球蛋白A（IgA）可预防URTI，且最近有研究表明牛初乳能增加唾液IgA，但几乎没有证据支持上述说法。
本研究旨在探讨浓缩牛初乳蛋白（CBC）是否会影响成年男性自我报告的URTI症状的发生率或持续时间。
我们查阅了之前研究中记录的自我报告疾病症状的日志，这些研究探讨了CBC的生理效应。在这些双盲、安慰剂对照研究中，受试者被随机分配，连续八周每天食用60克CBC（n = 93）或乳清蛋白（WP）（n = 81）。使用既定标准对症状进行编码，以识别与URTI相关的症状。由于URTI的潜伏期长达五天，因此对补充剂服用第一周（实验前）报告的症状进行单独分析，以排除研究开始前感染引起的症状。
在实验前阶段，服用不同补充剂且报告有URTI症状的受试者比例没有差异（CBC组为11%，WP组为5%；95%置信区间（95%CI）为-14%至2%；P = 0.16）。在随后的七周（即实验期）内，与服用WP的受试者相比，服用CBC的受试者报告有URTI症状的比例显著较低（CBC组为32%，WP组为48%，P = 0.03；95%CI为-30%至-2%），但症状持续时间没有差异（CBC组为6.8±4.2天，WP组为6.0±4.4天；P = 0.27）。
本研究提供了初步证据，表明CBC可能增强对URTI症状发生的抵抗力。
