Department of Biological Sciences, Faculty of Physical Culture in Gorzow Wielkopolski, Poznan University of Physical Education, Estkowskiego 13, 66-400 Gorzów Wielkopolski, Poland.
Department of Physiology, Collegium Medicum in Bydgoszcz, Nicolaus Copernicus University in Toruń, M. Sklodowskiej-Curie 9, 85-094 Bydgoszcz, Poland.
Nutrients. 2020 Dec 30;13(1):118. doi: 10.3390/nu13010118.
An intensive physical exercise program could lead to a decrease in immune system function. Effects of long-term supplementation of bovine colostrum on the response of immune function on physical exercise test in athletes were examined. Twenty-seven elite female basketball players (age 16-19) were randomly assigned to either an experimental group or a control group. Eventually, = 11 athletes completed intervention in the experimental group (3.2 g bovine colostrum orally twice a day for 24 weeks), while = 9 athletes in the control group were given a placebo. Before the supplementation, after 3 and 6 months, subjects performed the physical exercise stress test. Before, just after, and 3 h after physical exercise testing, blood was drawn and immune system indicators were examined. Plasma interleukin (IL)-1alpha, IL-2, IL-10, IL-13, tumor necrosis factor (TNF) alpha, creatine kinase (CK MM), immunoglobulin G (IgG), insulin-like growth factor 1 (IGF1), and WBC, lymphocyte (LYM), monocyte (MON), and granulocyte (GRA) were measured. A statistically significant change in IL-10 in response to the exercise program during the supplementation period in both groups was observed ( = 0.01). However, the results of the rest of the comparisons were statistically insignificant ( > 0.05). Contrary to our initial hypothesis, there were no significant effects of bovine supplementation on the dynamics of immune system function indicators.
一项剧烈的体育锻炼计划可能会导致免疫系统功能下降。本研究旨在探究长期补充牛初乳对运动员运动后免疫功能的影响。将 27 名 16-19 岁的优秀女性篮球运动员随机分为实验组和对照组。实验组（n=11）每天口服 3.2 克牛初乳，分两次服用，持续 24 周；对照组（n=9）服用安慰剂。在补充前、3 个月和 6 个月后，所有受试者都进行了运动压力测试。在运动前、运动后即刻和 3 小时后采集血液，检测免疫系统指标。检测血浆白细胞介素（IL）-1α、IL-2、IL-10、IL-13、肿瘤坏死因子（TNF）α、肌酸激酶同工酶（CK-MM）、免疫球蛋白 G（IgG）、胰岛素样生长因子 1（IGF1）和白细胞（WBC）、淋巴细胞（LYM）、单核细胞（MON）和粒细胞（GRA）。结果发现，两组在补充期间对运动方案的反应中，IL-10 均有统计学意义的变化（ = 0.01）。然而，其余比较的结果均无统计学意义（ > 0.05）。与我们最初的假设相反，牛初乳补充对免疫系统功能指标的动态变化没有显著影响。
