Artym Jolanta, Zimecki Michał
Department of Experimental Therapy, Hirszfeld Institute of Immunology and Experimental Therapy, Polish Academy of Sciences, R. Weigla 12 Str., 53-114 Wroclaw, Poland.
Biomedicines. 2023 Mar 27;11(4):1015. doi: 10.3390/biomedicines11041015.
In this article, we review the benefits of applying bovine colostrum (BC) and lactoferrin (LF) in animal models and clinical trials that include corticosteroid application and psychic stress, treatment with non-steroid anti-inflammatory drugs (NSAIDs) and antibiotics. A majority of the reported investigations were performed with native bovine or recombinant human LF, applied alone or in combination with probiotics, as nutraceutics and diet supplements. Apart from reducing adverse side effects of the applied therapeutics, BC and LF augmented their efficacy and improved the wellness of patients. In conclusion, LF and complete native colostrum, preferably administered with probiotic bacteria, are highly recommended for inclusion in therapeutic protocols in NSAIDs and corticosteroid anti-inflammatory, as well as antibiotic, therapies. These colostrum-based products can also be of value for individuals subjected to prolonged psychophysical stress (mediated by endogenous corticosteroids), especially at high ambient temperatures (soldiers and emergency services), as well as physically active people and training athletes. They are also recommended for patients during recovery from trauma and surgery, which are always associated with severe psychophysical stress.
在本文中，我们回顾了在动物模型和临床试验中应用牛初乳（BC）和乳铁蛋白（LF）的益处，这些试验包括应用皮质类固醇和精神压力、使用非甾体抗炎药（NSAIDs）和抗生素进行治疗。大多数已报道的研究使用的是天然牛乳铁蛋白或重组人乳铁蛋白，单独使用或与益生菌联合使用，作为营养保健品和膳食补充剂。除了减少所应用治疗药物的不良副作用外，BC和LF还增强了它们的疗效并改善了患者的健康状况。总之，强烈建议将LF和完整的天然初乳，最好与益生菌一起给药，纳入NSAIDs和皮质类固醇抗炎以及抗生素治疗的治疗方案中。这些基于初乳的产品对于遭受长期心理生理压力（由内源性皮质类固醇介导）的个体也有价值，特别是在高温环境下（士兵和应急服务人员），以及体育活动者和训练运动员。它们也被推荐给创伤和手术后正在康复的患者，这些情况总是与严重的心理生理压力相关。
