Ehrlich George E
University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, USA.
J Rheumatol Suppl. 2003 Aug;67:26-31.
Back pain is ubiquitous and probably plagues almost everyone in all cultures and ethnic groups at some time (around 20% annually), and in up to 50% of these at least once a year. The WHO-COPCORD epidemiologic investigations have established its prevalence even in countries that had been unaware of its frequency in their populace, and factors involving type of work and training probably accounted for this misperception. Medical journals are replete with articles addressing diagnosis and treatment, but the majority fail to meet the standards needed for metaanalysis or comparison. A task force of the Agency for Health Care Policy and Research of the United States Department of Health and Human Services screened more than 10,000 abstracts, eliminated the majority of these studies and papers, and still was unable to recommend the best approach even to acute back pain; the problem of subacute and chronic back pain is even more formidable. Yet back pain has been identified as perhaps the major cause of disability and absenteeism from the workplace worldwide. WHO chiefly addressed subacute back pain, as most acute back pain is self-limited and ends spontaneously, almost regardless of the treatment. Subacute pain is the intermediate stage toward chronic pain, which defies most treatments. Specific causes for back pain, such as infections, tumors, osteoporosis, spondyloarthropathies, and trauma, actually represent a minority of such pain syndromes, qualifying for specific therapeutic approaches. A major problem in defining the burden of disease for back pain has been a dearth of agreed-upon outcome measures by which to judge the various interventions, and this was the task that the WHO Low Back Pain Initiative took upon itself. Among measures recommended to be included in all studies, so that valid comparisons could be made, were measurement of pain by visual analog scales, somatic perception, the Oswestry disability and modified Zung questionnaires, and a modified Schober test of spinal mobility. These measures are needed for studies, not for diagnosis or treatment of individual patients. They have been translated into various major languages and validated by back-translations, and applied in comparative studies in various cultures to medical, chiropractic, and other common interventions. The importance of such scientifically sound studies cannot be overemphasized, as the costs of health care are mounting everywhere and it therefore becomes imperative to develop cost-effective approaches. All the more so as conversion of acute back pain to chronic back pain is often iatrogenic, with strong psychosocial factors as well, so that not only what to do but also what not to do become important public health issues. The general lack of attention to back pain by governments and organizations probably results from the fact that it is perceived as a syndromic presentation with myriad causes rather than as a specific disease entity. Even if the "disease" names classify like presentations but are not necessarily etiologically discrete, syndromic diagnoses that subsume a variety of causes receive less attention; international rankings of common disabilities and public health problems tend to emphasize the named disorders rather than the grouped disorders. Moreover, back pain is often self-treated with nonprescription medications or alternative therapies, and by nonmedical practitioners or treatments in many parts of the world. Validation of outcomes therefore not only reduces invalidism and direct costs but also reduces the indirect costs of absenteeism and medical care.
背痛普遍存在,几乎在所有文化和种族群体中,都可能在某个时候困扰着几乎每一个人(每年约20%),其中高达50%的人每年至少会经历一次。世界卫生组织慢性疼痛协作研究(WHO-COPCORD)的流行病学调查表明,即使在那些之前未意识到本国人口中背痛发病率的国家,背痛也普遍存在,工作类型和培训等因素可能导致了这种误解。医学期刊上充斥着关于背痛诊断和治疗的文章,但大多数都未达到进行荟萃分析或比较所需的标准。美国卫生与公众服务部医疗保健政策与研究局的一个特别工作组筛选了一万多篇摘要,剔除了其中的大部分研究和论文,即便如此,仍然无法就急性背痛的最佳治疗方法给出推荐;亚急性和慢性背痛问题则更加棘手。然而,背痛已被确认为全球范围内导致残疾和工作缺勤的主要原因之一。世界卫生组织主要关注亚急性背痛,因为大多数急性背痛是自限性的,几乎无论采用何种治疗方法,都会自行缓解。亚急性疼痛是通向慢性疼痛的中间阶段,而慢性疼痛对大多数治疗方法都有抵抗性。背痛的具体病因,如感染、肿瘤、骨质疏松症、脊柱关节病和创伤等,实际上只占此类疼痛综合征的少数,这些病因有特定的治疗方法。在确定背痛疾病负担方面的一个主要问题是,缺乏一致认可的用以评判各种干预措施的结果衡量标准,而这正是世界卫生组织腰痛倡议所承担的任务。在所有研究中建议纳入的用以进行有效比较的衡量标准包括:通过视觉模拟量表测量疼痛、躯体感觉、Oswestry功能障碍指数和改良的zung问卷,以及改良的Schober脊柱活动度测试。这些衡量标准是研究所需,而非用于个体患者的诊断或治疗。它们已被翻译成各种主要语言,并通过回译进行了验证,还应用于不同文化背景下针对医学、脊椎治疗及其他常见干预措施的比较研究中。这种科学严谨的研究的重要性无论如何强调都不为过,因为各地的医疗保健成本都在不断攀升,因此开发具有成本效益的方法变得势在必行。急性背痛转变为慢性背痛往往是医源性的,同时还伴有强烈的社会心理因素,所以不仅要知道该做什么,还要知道不该做什么,这都成为了重要的公共卫生问题。政府和组织对背痛普遍缺乏关注,可能是因为它被视为一种由多种原因导致的综合征表现,而非一种特定的疾病实体。即使“疾病”名称对类似表现进行了分类,但不一定在病因上是离散的,包含多种病因的综合征诊断受到的关注较少;常见残疾和公共卫生问题国际排名往往强调命名的疾病,而非归类的疾病。此外,在世界许多地方,背痛通常通过非处方药物或替代疗法自行治疗,或者由非医学从业者进行治疗。因此,对结果进行验证不仅可以减少无效治疗和直接成本,还可以降低旷工和医疗护理的间接成本。