Tronnikov S I, Gamaleia N B, Veretinskaia A G, Borisova E V, Sudakov S K, Anokhina I P
Biull Eksp Biol Med. 1992 Dec;114(12):624-6.
The paper demonstrates induction of antibodies to morphine and neurotransmitters (dopamine, norepinephrine, serotonin) in rats treated with intraperitoneal injections of morphine hydrochloride during 2 and 4 weeks in increasing doses. A contribution of such antibodies to the mechanisms of morphine tolerance and formation of physical dependence is considered.
