在啮齿动物和阿片类药物成瘾者的慢性吗啡治疗期间诱导产生针对吗啡的抗体。

Induction of antibodies to morphine during chronic morphine treatment in rodents and opiate addicts.

作者信息

Gamaleya N B, Parshin A N, Tronnikov S I, Yusupov D V

机构信息

Laboratory of Immunochemistry, Center of Addiction, Moscow, Russia.

出版信息

Drug Alcohol Depend. 1993 Mar;32(1):59-64. doi: 10.1016/0376-8716(93)90022-i.

DOI:10.1016/0376-8716(93)90022-i

PMID:8486085

Abstract

The phenomenon of induction of antibodies to morphine in morphine-treated animals and opiate addicts was shown by means of ELISA. The reaction of the immune system to injections of a morphine solution had the characteristics of a primary immune response. Opiate addicts differed from normal controls in the level of antibodies to morphine of IgM class. Elevated levels of such antibodies could be detected in about 70-80% of addicts with regular longterm opiate use when the time since the last drug intake did not exceed 60 days. Antibodies to morphine could serve as indicators of chronic opiate use especially in periods long after the last drug intake.

摘要

通过酶联免疫吸附测定法（ELISA）证实了在接受吗啡治疗的动物和阿片类药物成瘾者体内会诱导产生抗吗啡抗体的现象。免疫系统对注射吗啡溶液的反应具有初次免疫反应的特征。阿片类药物成瘾者与正常对照组在IgM类抗吗啡抗体水平上存在差异。当末次用药时间不超过60天时，在约70 - 80%有规律长期使用阿片类药物的成瘾者中可检测到此类抗体水平升高。抗吗啡抗体可作为长期使用阿片类药物的指标，尤其是在末次用药后的很长一段时间内。