Donenko F V, Sitdikova S M, Kabieva A O, Moroz L V
Biull Eksp Biol Med. 1992 Dec;114(12):652-4.
It was shown that surgical removal of Ehrlich carcinoma growing i. m. in male mice F1 (CBA C57Bl/6) does not entail longer survival in comparison with intact tumor-bearing mice (59.4 and 62.2 days, respectively). Postoperative relapses appear in 40-60% of the animals, metastases in 100% of animals. Metastases were not observed in intact tumor bearing mice. The second-challenge tumor was not observed in operated mice despite metastatic growth and recurrences of the same tumor. We suggest that metastatic growth depends on the tumor cell features and that this process is controlled by host organism.
结果表明，切除在雄性F1代（CBA×C57Bl/6）小鼠体内肌肉注射生长的艾氏癌，与未切除肿瘤的对照小鼠相比，生存期并未延长（分别为59.4天和62.2天）。40%-60%的动物术后出现复发，100%的动物出现转移。未切除肿瘤的对照小鼠未观察到转移。尽管手术小鼠出现转移生长和同一肿瘤复发，但未观察到二次攻击肿瘤。我们认为转移生长取决于肿瘤细胞特征，且该过程受宿主机体控制。
